Association of outcomes with depression
| Employment category | OR | 95% CI | P value | Complete obs (N) | OR (MR scale) | 95% CI (MR scale) |
| Not in paid employment | 2.27 | 2.21 to 2.33 | 0.0E+00 | 228 893 | 1.28 | 1.27 to 1.29 |
| Sick/disabled | 6.27 | 6.02 to 6.53 | 0.0E+00 | 185 421 | 1.74 | 1.72 to 1.76 |
| Caring for home/family | 1.43 | 1.35 to 1.51 | 2.2E-34 | 182 209 | 1.11 | 1.09 to 1.13 |
| Retired | 1.38 | 1.33 to 1.44 | 2.3E-51 | 204 399 | 1.10 | 1.09 to 1.12 |
| Unemployed | 2.13 | 1.99 to 2.28 | 4.3E-104 | 178 793 | 1.26 | 1.23 to 1.28 |
| Outcome | Beta | 95% CI | P value | Complete obs (N) | Beta (MR scale) | 95% CI (MR scale) |
| Townsend Deprivation Index | 0.80 | 0.765 to 0.83 | 0.0E+00 | 230 474 | 0.24 | 0.231 to 0.25 |
| Hours worked | −1.09 | −1.25 to to 0.93 | 2.8E-39 | 171 618 | −0.33 | −0.38 to –0.28 |
| Number in household | −0.23 | −0.25 to 0.22 | 2.3E-208 | 229 857 | −0.07 | −0.074 to –0.065 |
| Outcome | OR | 95% CI | P value | Complete obs (N) | OR (MR scale) | 95% CI (MR scale) |
| Highest educational attainment | 0.83 | 0.815 to 0.85 | 2.2E-65 | 229 041 | 0.95 | 0.94 to 0.952 |
| Household income | 0.53 | 0.515 to 0.54 | 0.0E+00 | 206 547 | 0.82 | 0.819 to 0.83 |
All associations are adjusted for age, sex, study assessment centre, and genetic principal components. Results for household income were obtained with or without additional adjustment for number in household (winsorised to 12). These results were not qualitatively different, results with adjustment are reported. Associations transformed onto the MR scale (columns suffixed ‘(MR Scale)’) assumed a depression prevalence of 15%