Men: multivariate linear regression analysis of men’s main and joint effects of breakups/years lived alone and highest attained educational level on IL-6 or CRP
| Partnership breakups: hsCRP | Partnership breakups: IL-6 | ||||||||||
| N | Estimate, mean | Coefficient, mg/L | 95% CI | P value | N | Estimate, mean | Coefficient, pg/mL | 95% CI | P value | ||
| Breakups | 0.0102 | Breakups | 0.0822 | ||||||||
| None (0) | 1810 | 1.49 | – | – | None (0) | 1810 | 2.87 | – | – | ||
| One or more (1+) | 1360 | 1.63 | 1.10 | 1.02 to 1.18 | One or more (1+) | 1360 | 3.01 | 1.05 | 0.99 to 1.11 | ||
| Educational level* | 0.0364 | Educational level* | 0.0120 | ||||||||
| High | 2580 | 1.49 | – | – | High | 2580 | 2.81 | – | – | ||
| Low | 590 | 1.63 | 1.10 | 1.01 to 1.20 | Low | 590 | 3.07 | 1.09 | 1.02 to 1.17 | ||
| Interaction† | 0.7453 | Interaction† | 0.5554 | ||||||||
| High/ 0 | 1516 | 1.42 | – | – | High/ 0 | 1516 | 2.74 | – | – | ||
| High/ 1+ | 363 | 1.72 | 1.21 | 1.08 to 1.36 | High/ 1+ | 363 | 3.32 | 1.21 | 1.11 to 1.32 | ||
| Low/ 0 | 294 | 1.58 | 1.11 | 0.99 to 1.26 | Low/ 0 | 294 | 3.01 | 1.10 | 1.00 to 1.21 | ||
| Low/ 1+ | 997 | 1.54 | 1.09 | 1.01 to 1.18 | Low/ 1+ | 997 | 2.80 | 1.02 | 0.96 to 1.09 | ||
| Years lived alone: hsCRP | Years lived alone: IL-6 | ||||||||||
| N | Estimate, mean | Coefficient, mg/L | 95% CI | P value | N | Estimate, mean | Coefficient, pg/mL | 95% CI | P value | ||
| Years lived alone | 0.0256 | Years lived alone | <0.0001 | ||||||||
| 0–1 year | 1693 | 1.30 | – | – | 0–1 year | 1693 | 2.69 | – | – | ||
| 2–6 years | 716 | 1.30 | 1.00 | 0.92 to 1.09 | 2–6 years | 716 | 2.56 | 0.95 | 0.89 to 1.02 | ||
| 7+ years | 927 | 1.44 | 1.11 | 1.03 to 1.21 | 7+ years | 927 | 3.01 | 1.12 | 1.05 to 1.19 | ||
| Educational level* | 0.0359 | Educational level* | 0.02 | ||||||||
| High | 2692 | 1.28 | – | – | High | 2692 | 2.64 | – | – | ||
| Low | 644 | 1.41 | 1.10 | 1.01 to 1.20 | Low | 644 | 2.85 | 1.08 | 1.01 to 1.15 | ||
| Interaction† | 0.3679 | Interaction† | 0.3512 | ||||||||
| High/ 0–1 year | 1411 | 1.24 | – | – | High/ 0–1 year | 1411 | 2.57 | – | – | ||
| High/ 2–6 years | 581 | 1.21 | 0.97 | 0.88 to 1.06 | High/ 2–6 years | 581 | 2.48 | 0.96 | 0.90 to 1.04 | ||
| High/ 7+ years | 700 | 1.39 | 1.12 | 1.02 to 1.22 | High/ 7+ years | 700 | 2.94 | 1.14 | 1.07 to 1.23 | ||
| Low/ 1–0 year | 282 | 1.32 | 1.06 | 0.93 to 1.20 | Low/ 1–0 years | 282 | 2.92 | 1.14 | 1.03 to 1.25 | ||
| Low/ 2–6 years | 135 | 1.51 | 1.21 | 1.01 to 1.44 | Low/ 2–6 years | 135 | 2.61 | 1.01 | 0.89 to 1.16 | ||
| Low/ 7+ years | 227 | 1.48 | 1.18 | 1.03 to 1.36 | Low/ 7+ years | 227 | 3.01 | 1.18 | 1.06 to 1.31 | ||
Models adjusted for: gender, age, cohort, chronic diseases, acute inflammatory events, pharmaceutical intake, eMLE, BMI, personality. P values for the product term. Statistically significant estimates are presented in bold.
*Education: highest attained educational level.
†Test for interaction by the inclusion of a product term: partnership breakups + education + partnership breakups x education + covariates,
BMI, body mass index; eMLE, early major life events; hsCRP, high sensitivity C-reactive protein; IL-6, interleukin 6.