Table 3

Men: multivariate linear regression analysis of men’s main and joint effects of breakups/years lived alone and highest attained educational level on IL-6 or CRP

Partnership breakups: hsCRPPartnership breakups: IL-6
NEstimate, meanCoefficient, mg/L95% CIP valueNEstimate, meanCoefficient, pg/mL95% CIP value
Breakups 0.0102 Breakups 0.0822
None (0)18101.49None (0)18102.87
One or more (1+)13601.631.101.02 to 1.18One or more (1+)13603.011.050.99 to 1.11
Educational level* 0.0364 Educational level* 0.0120
High25801.49High25802.81
Low5901.631.101.01 to 1.20Low5903.071.091.02 to 1.17
Interaction0.7453 Interaction0.5554
High/ 015161.42High/ 015162.74
High/ 1+3631.721.211.08 to 1.36High/ 1+3633.321.211.11 to 1.32
Low/ 02941.581.110.99 to 1.26Low/ 02943.011.101.00 to 1.21
Low/ 1+9971.541.091.01 to 1.18Low/ 1+9972.801.020.96 to 1.09
Years lived alone: hsCRPYears lived alone: IL-6
NEstimate, meanCoefficient, mg/L95% CIP valueNEstimate, meanCoefficient, pg/mL95% CIP value
Years lived alone 0.0256 Years lived alone <0.0001
0–1 year16931.300–1 year16932.69
2–6 years7161.301.000.92 to 1.092–6 years7162.560.950.89 to 1.02
7+ years9271.441.111.03 to 1.217+ years9273.011.121.05 to 1.19
Educational level* 0.0359 Educational level* 0.02
High26921.28High26922.64
Low6441.411.101.01 to 1.20Low6442.851.081.01 to 1.15
Interaction0.3679 Interaction0.3512
High/ 0–1 year14111.24High/ 0–1 year14112.57
High/ 2–6 years5811.210.970.88 to 1.06High/ 2–6 years5812.480.960.90 to 1.04
High/ 7+ years7001.391.121.02 to 1.22High/ 7+ years7002.941.141.07 to 1.23
Low/ 1–0 year2821.321.060.93 to 1.20Low/ 1–0 years2822.921.141.03 to 1.25
Low/ 2–6 years1351.511.211.01 to 1.44Low/ 2–6 years1352.611.010.89 to 1.16
Low/ 7+ years2271.481.181.03 to 1.36Low/ 7+ years2273.011.181.06 to 1.31
  • Models adjusted for: gender, age, cohort, chronic diseases, acute inflammatory events, pharmaceutical intake, eMLE, BMI, personality. P values for the product term. Statistically significant estimates are presented in bold.

  • *Education: highest attained educational level.

  • †Test for interaction by the inclusion of a product term: partnership breakups + education + partnership breakups x education + covariates,

  • BMI, body mass index; eMLE, early major life events; hsCRP, high sensitivity C-reactive protein; IL-6, interleukin 6.