Table 1

Segmented regression of time-series results expressed in defined daily doses—prescription of anxiolytics, sedatives and hypnotics

	Immediate impact		Change in trend		Absolute change in outcome a month after COVID-19	Relative change in outcome a month after COVID-19 (%)
	B	95% CI	B	95% CI	Absolute change in outcome a month after COVID-19	Relative change in outcome a month after COVID-19 (%)
Male
Children (≥7 yo)	−3795.81*	−5361.47 to −2230.15	−0.36	−179.70 to 178.99	−3796.17	−47.60
Adolescents (8–17 yo)	−2899.09*	−5673.12 to −125.05	122.73	−188.30 to 433.77	−2776.35	−10.57
Adults (18–64 yo)	−168 291.27	−439 366.75 to 102 784.21	27 129.40	−3468.68 to 57 727.48	−141 161.87	−5.74
Older adults (65–74 yo)	−34 403.70	−100 896.53 to 32 089.14	13 162.11*	4929.03 to 21 395.18	−21 241.59	−1.58
Elderly (≥75 yo)	−30 939.04	−94 317.29 to 32 439.20	14 582.46*	6863.67 to 22 301.26	−16 356.58	−1.25
Female
Children (≥7 yo)	−2938.74*	−3966.10 to −1911.38	−26.05	−133.60 to 81.50	−2964.79	−47.82
Adolescents (8–17 yo)	−7142.78*	−12 399.81 to −1885.75	521.04	−5.99 to 1048.07	−6621.74	−27.46
Adults (18–64 yo)	−80 580.27	−676 807.98 to 515 647.44	45 887.32	−23 833.17 to 115 607.81	−34 692.95	−0.77
Older adults (65–74 yo)	−186 383.98	−374 446.64 to 1678.67	40 328.93*	17 743.87 to 62 913.98	−146 055.06	−4.50
Elderly (≥75 yo)	−330 938.28*	−516 988.89 to −144887.66	55 986.34*	34 033.34 to 77 939.34	−274 951.94	−7.20
Total	−724 445.94	−1 881 469.52 to 432 577.63	185 245.64*	40 314.44 to 330 176.85	−539 200.30	−3.37