Table 2

Association between UF and diagnosis of mental health outcomes, overall and stratified by race/ethnicity

DepressionAnxietySelf-directed violence
Diagnosed
UF
No diagnosed
UF
Diagnosed
UF
No diagnosed
UF
Diagnosed
UF
No diagnosed
UF
Overall
 n313 754627 539313 754627 539313 754627 539
 Events, n26 17146 10334 00360 683509616
 Days between index date and outcome diagnosis, median (IQR)609 (240, 1330)607 (234, 1313)596 (234, 1302)596 (229, 1289)670 (264, 1471)662 (256, 1432)
 Rate per 1000 person-years30.927.841.037.30.60.3
 Age-matched HR (95% CI)1.12 (1.10 to 1.13)1.0 (Ref)1.10 (1.09 to 1.12)1.0 (Ref)1.60 (1.42 to 1.80)1.0 (Ref)
 Adjusted HR (95% CI)*1.12 (1.10 to 1.13)1.0 (Ref)1.12 (1.10 to 1.13)1.0 (Ref)1.46 (1.29 to 1.64)1.0 (Ref)
Non-Hispanic White
 n168 479429 656168 479429 656168 479429 656
 Events, n15 88834 61220 24044 905263430
 Rate per 1000 person-years34.129.644.439.10.50.3
 Age-matched HR (95% CI)1.16 (1.14 to 1.18)1.0 (Ref)1.14 (1.12 to 1.15)1.0 (Ref)1.51 (1.29 to 1.76)1.0 (Ref)
 Adjusted HR (95% CI)*1.13 (1.10 to 1.15)1.0 (Ref)1.12 (1.10 to 1.14)1.0 (Ref)1.41 (1.21 to 1.65)1.0 (Ref)
Non-Hispanic Black
 n74 60166 36574 60166 36574 60166 365
 Events, n546543836937547914181
 Rate per 1000 person-years27.526.835.533.90.70.5
 Age-matched HR (95% CI)1.04 (1.00 to 1.08)1.0 (Ref)1.05 (1.02 to 1.09)1.0 (Ref)1.43 (1.09 to 1.88)1.0 (Ref)
 Adjusted HR (95% CI)*1.03 (0.99 to 1.07)1.0 (Ref)1.05 (1.02 to 1.09)1.0 (Ref)1.38 (1.05 to 1.82)1.0 (Ref)
Hispanic
 n46 89880 93246 89880 93246 89880 932
 Events, n38215390523076537879
 Rate per 1000 person-years32.427.845.540.50.60.4
 Age-matched HR (95% CI)1.17 (1.13 to 1.22)1.0 (Ref)1.13 (1.09 to 1.17)1.0 (Ref)1.60 (1.17 to 2.19)1.0 (Ref)
 Adjusted HR (95% CI)*1.15 (1.10 to 1.20)1.0 (Ref)1.11 (1.08 to 1.15)1.0 (Ref)1.57 (1.14 to 2.15)1.0 (Ref)
Asian
 n23 77650 58623 77650 58623 77650 586
 Events, n9971718159626462726
 Rate per 1000 person-years15.613.225.520.60.40.2
 Age-matched HR (95% CI)1.19 (1.10 to 1.29)1.0 (Ref)1.24 (1.17 to 1.32)1.0 (Ref)2.09 (1.22 to 3.57)1.0 (Ref)
 Adjusted HR (95% CI)*1.17 (1.08 to 1.27)1.0 (Ref)1.23 (1.16 to 1.31)1.0 (Ref)1.98 (1.15 to 3.41)1.0 (Ref)
  • *HR adjusted for race, region of residence, allergic rhinitis, asthma, irritable bowel syndrome (IBS), eczema, chronic low back pain, fatigue, vitamin D deficiency, chronic headaches/migraines, thyroid disease, hypothyroidism, type 2 diabetes mellitus, hyperlipidaemia, hypertension, fibromyalgia, live birth and use of antihypertensives, corticosteroids, non-opioid analgesics, opioid analgesics, combined hormonal contraceptives, statins, oral progestin, depot medroxyprogesterone acetate or progestogen-releasing intrauterine system. Race-stratified models adjusted for all the covariates listed above except race.

  • UF, uterine fibroid.