Association between hysterectomy after UF diagnosis and diagnosis of mental health outcomes, restricted to women with diagnosed UF
| Hysterectomy | No hysterectomy | |
| n | 50 525 | 101 942 |
| Depression | ||
| Events, n | 4368 | 6588 |
| Days between index date and outcome diagnosis, median (IQR) | 638 (247, 1394) | 612 (235, 1330) |
| Rate per 1000 person-years | 31.1 | 24.3 |
| Age-matched HR (95% CI) | 1.29 (1.24 to 1.34) | 1.0 (Ref) |
| Adjusted HR (95% CI)* | 1.22 (1.17 to 1.27) | 1.0 (Ref) |
| Anxiety | ||
| Events, n | 5259 | 8970 |
| Days between index date and outcome diagnosis, median (IQR) | 631 (245, 1378) | 601 (231, 1302) |
| Rate per 1000 person-years | 38.0 | 33.7 |
| Age-matched HR (95% CI) | 1.13 (1.09 to 1.17) | 1.0 (Ref) |
| Adjusted HR (95% CI)* | 1.13 (1.09 to 1.17) | 1.0 (Ref) |
| Self-directed violence | ||
| Events, n | 99 | 97 |
| Days between index date and outcome diagnosis, median (IQR) | 704 (271, 1546) | 657 (253, 1435) |
| Rate per 1000 person-years | 0.7 | 0.3 |
| Age-matched HR (95% CI) | 1.94 (1.47 to 2.57) | 1.0 (Ref) |
| Adjusted HR (95% CI)* | 1.86 (1.39 to 2.49) | 1.0 (Ref) |
*HR adjusted for race, region of residence, allergic rhinitis, asthma, irritable bowel syndrome (IBS), eczema, chronic low back pain, fatigue, vitamin D deficiency, chronic headaches/migraines, thyroid disease, hypothyroidism, type 2 diabetes mellitus, hyperlipidaemia, hypertension, fibromyalgia, live birth and use of antihypertensives, corticosteroids, non-opioid analgesics, opioid analgesics, combined hormonal contraceptives, statins, oral progestin, depot medroxyprogesterone acetate, progestogen-releasing intrauterine system, prior myomectomy and prior uterine artery embolisation (UAE).
UF, uterine fibroid.