Table 4

Association between hysterectomy after UF diagnosis and diagnosis of mental health outcomes, restricted to women with diagnosed UF

HysterectomyNo hysterectomy
n50 525101 942
 Events, n43686588
 Days between index date and outcome diagnosis, median (IQR)638 (247, 1394)612 (235, 1330)
 Rate per 1000 person-years31.124.3
 Age-matched HR (95% CI)1.29 (1.24 to 1.34)1.0 (Ref)
 Adjusted HR (95% CI)*1.22 (1.17 to 1.27)1.0 (Ref)
 Events, n52598970
 Days between index date and outcome diagnosis, median (IQR)631 (245, 1378)601 (231, 1302)
 Rate per 1000 person-years38.033.7
 Age-matched HR (95% CI)1.13 (1.09 to 1.17)1.0 (Ref)
 Adjusted HR (95% CI)*1.13 (1.09 to 1.17)1.0 (Ref)
Self-directed violence
 Events, n9997
 Days between index date and outcome diagnosis, median (IQR)704 (271, 1546)657 (253, 1435)
 Rate per 1000 person-years0.70.3
 Age-matched HR (95% CI)1.94 (1.47 to 2.57)1.0 (Ref)
 Adjusted HR (95% CI)*1.86 (1.39 to 2.49)1.0 (Ref)
  • *HR adjusted for race, region of residence, allergic rhinitis, asthma, irritable bowel syndrome (IBS), eczema, chronic low back pain, fatigue, vitamin D deficiency, chronic headaches/migraines, thyroid disease, hypothyroidism, type 2 diabetes mellitus, hyperlipidaemia, hypertension, fibromyalgia, live birth and use of antihypertensives, corticosteroids, non-opioid analgesics, opioid analgesics, combined hormonal contraceptives, statins, oral progestin, depot medroxyprogesterone acetate, progestogen-releasing intrauterine system, prior myomectomy and prior uterine artery embolisation (UAE).

  • UF, uterine fibroid.