Table 3

Adjusted stage-specific HRs and excess HRs of death for patients with colon and rectal cancer, England, January 2010–March 2013

Colon (n=38 070)Rectum (n=22 631)
Overall survivalOverall survivalNet survivalOverall survivalOverall survivalNet survival
Cox modela FPM with TVCsb FPM with TVCsc Cox modeld FPM with TVCse FPM with TVCsf
Adjusted HR95% CIAdjusted HR95% CIAdjusted EHR95% CIAdjusted HR95% CIAdjusted HR95% CIAdjusted EHR95% CI
Stage I
 SES 1 (affluent)ReferenceReferenceReferenceReferenceReferenceReference
 21.040.79 to 1.371.030.78 to 1.371.100.49 to 2.461.020.77 to 1.341.020.77 to 1.341.330.56 to 3.14
 30.990.74 to 1.320.990.74 to 1.320.650.23 to 1.821.110.85 to 1.451.110.85 to 1.461.400.59 to 3.29
 41.070.80 to 1.431.070.80 to 1.431.160.51 to 2.671.140.87 to 1.491.140.87 to 1.501.320.55 to 3.18
 5 (deprived)1.180.88 to 1.591.200.89 to 1.601.560.71 to 3.441.441.09 to 1.901.451.10 to 1.912.000.86 to 4.66
Stage II
 SES 1ReferenceReferenceReferenceReferenceReferenceReference
 21.030.89 to 1.181.020.89 to 1.180.970.76 to 1.250.980.80 to 1.200.980.80 to 1.210.890.64 to 1.24
 31.110.97 to 1.281.110.97 to 1.281.010.78 to 1.301.150.95 to 1.401.150.95 to 1.401.150.85 to 1.55
 41.381.20 to 1.581.371.19 to 1.571.531.21 to 1.931.140.94 to 1.391.140.94 to 1.391.160.86 to 1.57
 51.451.26 to 1.671.431.24 to 1.651.561.22 to 1.991.331.08 to 1.631.331.09 to 1.641.411.04 to 1.91
Stage III
 SES 1ReferenceReferenceReferenceReferenceReferenceReference
 21.161.05 to 1.291.171.05 to 1.291.161.02 to 1.320.980.85 to 1.130.980.84 to 1.130.960.80 to 1.16
 31.110.99 to 1.231.111.00 to 1.231.060.93 to 1.221.070.93 to 1.241.070.93 to 1.241.040.86 to 1.25
 41.191.07 to 1.321.201.08 to 1.331.130.98 to 1.291.110.96 to 1.281.110.96 to 1.281.100.91 to 1.32
 51.331.19 to 1.481.331.19 to 1.491.291.12 to 1.481.080.93 to 1.251.080.93 to 1.251.040.85 to 1.26
Stage IV
 SES 1ReferenceReferenceReferenceReferenceReferenceReference
 20.960.90 to 1.040.970.90 to 1.040.960.89 to 1.040.950.85 to 1.050.950.85 to 1.050.950.85 to 1.06
 31.000.93 to 1.071.000.93 to 1.070.980.91 to 1.061.000.90 to 1.111.000.90 to 1.110.990.89 to 1.11
 41.040.96 to 1.121.040.97 to 1.121.030.95 to 1.110.960.87 to 1.070.970.87 to 1.080.940.84 to 1.05
 50.990.92 to 1.080.990.92 to 1.080.960.89 to 1.051.151.03 to 1.281.141.03 to 1.271.090.97 to 1.22
  • Interaction between SES and stage is added for all models. Calculated for complete cases only.

  • Model a, b, c: adjusted for sex, age, site, tumour grade, emergency presentation, receipt of major resection, number of chronic and acute comorbidities.

  • Model d, e, f: adjusted for sex, age, year of diagnosis, site, tumour grade, emergency presentation, receipt of major resection, number of chronic and acute comorbidities.

  • EHR, excess HR; FPM, flexible parametric model; SES, socioeconomic status; TVC, time-varying covariate.