Sex-adjusted regression models of the association of intergenerational social class change (between age 4 and age 53) with four DNA methylation AA markers measured at age 53 in men and women (n=1273)
| Horvath AA | Hannum AA | PhenoAge AA | GrimAge AA | |
| Coeff. (95% CI) | Coeff. (95% CI) | Coeff. (95% CI) | Coeff. (95% CI) | |
| Intergenerational social class change | ||||
| Stable non-manual | Reference | Reference | Reference | Reference |
| Non-manual to manual | 0.76 (−0.11 to 1.64) | 0.45 (−0.45 to 1.34) | 0.63 (−0.58 to 1.84) | 1.74 (0.69 to 2.78) |
| Manual to non-manual | 0.06 (−0.48 to 0.60) | 0.98 (0.43 to 1.53) | 1.05 (0.30 to 1.79) | 1.27 (0.62 to 1.92) |
| Stable manual | 0.19 (−0.40 to 0.77) | 0.62 (0.03 to 1.22) | 1.39 (0.58 to 2.19) | 2.62 (1.92 to 3.32) |
AA, age acceleration.