Table 2

HRs (95% CI) for the association between salivary cotinine and mortality in 36 584 non-smokers

Salivary cotinine (ng/mL)Salivary cotinineP value for trendContinuous salivary cotinine
Tertile 1 (low)Tertile 2Tertile 3Per 10 ng/mL increase
Range0–0.1>0.1–0.5>0.5–14.9
Mean0.030.322.01
Total mortality
No. of deaths 814701850
Age and sex adjusted1 (Ref)0.95 (0.86 to 1.05)1.25 (1.14 to 1.38)0.0011.74 (1.40 to 2.18)
Multiple adjusted*10.91 (0.83 to 1.01)1.18 (1.07 to 1.30)0.0021.46 (1.16 to 1.83)
Cardiovascular disease mortality
No. of deaths 264227284
Age and sex adjusted10.97 (0.81 to 1.16)1.33 (1.13 to 1.58)0.0011.78 (1.21 to 2.61)
Multiple adjusted*10.91 (0.76 to 1.09)1.22 (1.03 to 1.45)0.0251.41 (0.96 to 2.09)
Cancer mortality
No. of deaths 275216288
Age and sex adjusted10.85 (0.71 to 1.011.20 (1.01 to 1.42)0.0361.73 (1.17 to 2.55)
Multiple adjusted*10.83 (0.69 to 0.99)1.13 (0.95 to 1.34)0.1751.49 (1.00 to 2.22)
Smoking-related cancer mortality
No. of deaths 9075124
Age and sex adjusted10.90 (0.66 to 1.23)1.57 (1.19 to 2.06)0.0013.20 (1.95 to 5.22)
Multiple adjusted*10.88 (0.64 to 1.19)1.43 (1.08 to 1.89)0.0102.92 (1.77 to 4.83)
  • *Adjusted for sex, age, survey, social class, long-standing illness and alcohol intake.