Rate difference in additional coronary heart disease events per 100 000 person-years by educational level (decomposition of total effect into direct, indirect and mediated interaction effects) in men and women
| Mediator* | Men | Women | ||||
| Educational Level† | Proportion mediated in low education (95% CI) | Educational level † | Proportion mediated in low education (95% CI) | |||
| Low | Intermediate | Low | Intermediate | |||
| RD (95% CI)‡ | RD (95% CI)‡ | RD (95% CI)‡ | RD (95% CI)‡ | |||
| Allostatic load score | ||||||
| Total effect | 246 (173 to 319) | 131 (56 to 206) | 157 (110 to 204) | 64 (14 to 114) | ||
| Pure direct effect (PDE) | 201 (128 to 273) | 100 (26 to 174) | 100 (55 to 146) | 40 (−10 to 90) | ||
| Pure indirect effect (PIE) | 39 (33 to 44) | 35 (31 to 40) | 16 (11 to 23) | 44 (35 to 54) | 27 (23 to 32) | 28 (19 to 44) |
| Mediated interaction (MI) | 7 (0 to 14) | −4 (−9 to 0) | 3 (0 to 6) | 12 (0 to 25) | −3 (−7 to 1) | 8 (0 to 16) |
| Smoking § | ||||||
| Total effect | 250 (176 to 325) | 134 (59 to 209) | 158 (112 to 204) | 65 (15 to 114) | ||
| PDE | 181 (110 to 253) | 92 (17 to 166) | 133 (88 to 177) | 58 (8 to 107) | ||
| PIE | 58 (47 to 68) | 46 (39 to 52) | 23 (16 to 34) | 17 (12 to 23) | 9 (6 to 12) | 11 (7 to 17) |
| MI | 12 (−2 to 25) | −3 (−10 to 4) | 5 (−1 to 10) | 8 (−1 to 17) | −2 (−5 to 0) | 5 (−1 to 11) |
| Alcohol¶ | ||||||
| Total effect | 240 (167 to 313) | 126 (52 to 200) | 156 (110 to 202) | 63 (14 to 113) | ||
| PDE | 241 (167 to 314) | 127 (51 to 202) | 144 (98 to 190) | 59 (9 to 108) | ||
| PIE | 6 (-5 to 18) | −1 (−7 to 5) | 3 (−2 to 8) | 11 (6 to 16) | 5 (3 to 7) | 7 (4 to 12) |
| MI | −7 (−21 to 7) | 0 (−6 to 5) | −3 (−10 to 3) | 1 (−7 to 9) | 0 (−2 to 2) | 1 (−5 to 6) |
| Body mass index | ||||||
| Total effect | 246 (173 to 319) | 131 (57 to 205) | 152 (106 to 198) | 60 (10 to 109) | ||
| PDE | 235 (162 to 308) | 121 (47 to 195) | 135 (89 to 181) | 51 (1 to 100) | ||
| PIE | 13 (7 to 18) | 9 (5 to 14) | 5 (3 to 9) | 17 (9 to 25) | 9 (5 to 14) | 11 (6 to 19) |
| MI | −1 (−9 to 7) | 1 (−4 to 5) | 0 (−4 to 3) | 0 (−12 to 12) | −1 (-4 to 3) | 0 (−9 to 8) |
*Analysis adjusted for age and population.
†Reference category was considered high education.
‡This was estimated from the additive hazard survival model, with age on the time scale and adjusting for population.
§In men smoking categorised as; never smoker, 1–10 cigs/day, 11–20 cigs/day,>20 cigs/day. For women smoking categories included; never smokers,1–10 cigs///day,≥1 cigs/day.
¶In men alcohol use categorised as; teetotalers, 1–2 drinks/day, 3–4 drinks/day,≥5 drinks/day. For women alcohol categories included teetotalers, 1–2 drinks/day, ≥3 drinks/day.
RD, risk difference.