Table 4

Rate difference in additional coronary heart disease events per 100 000 person-years by educational level (decomposition of total effect into direct, indirect and mediated interaction effects) for allostatic load as mediators, separately for individuals in the pre-dysregulation and in the dysregulation phases

Allostatic load score*MenWomen
Educational level †Proportion mediated in low education (95% CI)Educational level †Proportion mediated in low education (95% CI)
LowIntermediateLowIntermediate
RD (95% CI)‡RD (95% CI)‡RD (95% CI)‡RD (95% CI)‡
Pre-dysregulation
 Total effect213 (128 to 298)129 (40 to 219)118 (68 to 168)50 (−3 to 103)
 Pure direct effect (PDE)186 (103 to 269)111 (22 to 199)87 (38 to 135)40 (−13 to 93)
 Pure indirect effect (PIE)22 (17 to 27)21 (17 to 26)10 (6 to 18)19 (11 to 28)13 (9 to 18)16 (8 to 32)
 Mediated interaction (MI)5 (−2 to 12)−3 (−8 to 3)2 (−1 to 5)12 (0 to 24)−3 (−7 to 0)10 (0 to 21)
Dysregulation
 Total effect242 (125 to 358)107 (-9 to 222)179 (102 to 256)69 (-14 to 152)
 PDE214 (98 to 330)88 (-27 to 203)130 (55 to 204)54 (-30 to 137)
 PIE24 (19 to 28)21 (17 to 25)10 (6 to 20)33 (23 to 43)17 (14 to 21)19 (11 to 37)
 MI4 (−2 to 9)−3 (−7 to 1)2 (−1 to 4)16 (1 to 30)−3 (−7 to 1)9 (1 to 18)
  • *Analysis adjusted for age and centre.

  • †Reference category included high education.

  • ‡This was estimated from the additive hazard survival model, with age on the time scale and adjusting for population.

  • RD, risk difference.