Rate difference in additional coronary heart disease events per 100 000 person-years by educational level (decomposition of total effect into direct, indirect and mediated interaction effects) for allostatic sub-scores as mediators in men and women
| Allostatic load sub-score* | Men | Women | ||||
| Educational level † | Proportion mediated in low education (95% CI) | Educational level † | Proportion mediated in low education (95% CI) | |||
| Low | Intermediate | Low | Intermediate | |||
| RD (95% CI)‡ | RD (95% CI)‡ | RD (95% CI)‡ | RD (95% CI)‡ | |||
| Cardiovascular system | ||||||
| Total effect | 245 (173 to 318) | 130 (56 to 204) | 158 (112 to 204) | 64 (16 to 113) | ||
| Pure direct effect (PDE) | 236 (163 to 308) | 125 (51 to 199) | 146 (101 to 192) | 57 (9 to 106) | ||
| Pure indirect effect (PIE) | 7 (5 to 9) | 8 (6 to 10) | 3 (2 to 5) | 10 (6 to 13) | 7 (4 to 9) | 6 (4 to 10) |
| Mediated interaction (MI) | 3 (0 to 5) | −3 (−5 to 0) | 1 (0 to 2) | 2 (−3 to 7) | 0 (−2 to 3) | 1 (−2 to 4) |
| Metabolic system | ||||||
| Total effect | 247 (174 to 320) | 131 (57 to 205) | 154 (107 to 201) | 61 (11 to 111) | ||
| PDE | 219 (146 to 291) | 109 (36 to 182) | 106 (61 to 151) | 40 (−10 to 91) | ||
| PIE | 26 (22 to 31) | 22 (19 to 26) | 11 (8 to 16) | 41 (31 to 51) | 22 (18 to 26) | 27 (17 to 42) |
| MI | 2 (−4 to 7) | 0 (−4 to 4) | 1 (−2 to 2) | 7 (−6 to 21) | −2 (−6 to 2) | 5 (−5 to 13) |
| Inflammation | ||||||
| Total effect | 246 (173 to 319) | 131 (57 to 206) | 158 (112 to 204) | 64 (15 to 114) | ||
| PDE | 204 (132 to 276) | 110 (36 to 184) | 126 (81 to 172) | 55 (6 to 105) | ||
| PIE | 30 (24 to 36) | 30 (25 to 34) | 12 (9 to 18) | 18 (13 to 23) | 13 (11 to 16) | 11 (7 to 18) |
| MI | 12 (5 to 20) | −8 (−13 to −3) | 5 (2 to 8) | 14 (6 to 22) | −4 (−6 to −2) | 9 (4 to 14) |
*Analysis adjusted for age and centre.
†Reference category included high education.
‡This was estimated from the additive hazard survival model, with age on the time scale and adjusting for population.
RD, Risk difference.