Cases | Controls | OR (95% CI)† | Cases | Controls | OR (95% CI)† | |
A | ||||||
Sex p=0.051‡ | Men | Women | ||||
1st quartile (m: 51–78/w: 49–78)§ | 489 | 1520 | 1 | 109 | 307 | 1 |
2nd quartile (m: 41–50/w: 40–48)§ | 971 | 1408 | 1.55 (1.34 to 1.81) | 152 | 346 | 1.27 (0.91 to 1.77) |
3rd quartile (m: 32–40/w: 26–39)§ | 1534 | 1384 | 1.98 (1.70 to 2.30) | 158 | 303 | 1.18 (0.84 to 1.66) |
4th quartile (m: 14–31/w: 14–25)§ | 2191 | 1751 | 1.99 (1.71 to 2.30) | 214 | 307 | 1.48 (1.00 to 2.19) |
Study region p<0.001‡ | Europe | Latin America | ||||
1st quartile (49–78) | 564 | 1819 | 1 | 72 | 81 | 1 |
2nd quartile (40–48) | 1035 | 1763 | 1.42 (1.23 to 1.63) | 283 | 194 | 1.41 (0.93 to 2.15) |
3rd quartile (31–39) | 1507 | 1447 | 1.71 (1.48 to 1.98) | 575 | 394 | 1.21 (0.82 to 1.80) |
4th quartile (14–30) | 1129 | 1103 | 1.80 (1.54 to 2.11) | 653 | 525 | 1.21 (0.81 to 1.81) |
Type of study p<0.001‡ | Hospital based | Population based | ||||
1st quartile (49–78) | 301 | 432 | 1 | 335 | 1468 | 1 |
2nd quartile (40–48) | 717 | 682 | 1.20 (0.97 to 1.47) | 601 | 1275 | 1.58 (1.32 to 1.90) |
3rd quartile (31–39) | 1241 | 855 | 1.27 (1.04 to 1.56) | 841 | 986 | 1.98 (1.65 to 2.39) |
4th quartile (14–30) | 1085 | 918 | 1.18 (0.95 to 1.46) | 697 | 710 | 2.35 (1.93 to 2.86) |
Ever/never smoked cigarettes p=0.132‡ | Ever smoked ≥100 cigarettes | Never smoked ≥100 cigarettes | ||||
1st quartile (49–78) | 561 | 1175 | 1 | 75 | 725 | 1 |
2nd quartile (40–48) | 1212 | 1271 | 1.57 (1.36 to 1.82) | 106 | 686 | 1.34 (0.96 to 1.86) |
3rd quartile (31–39) | 2004 | 1320 | 1.89 (1.64 to 2.18) | 78 | 521 | 1.21 (0.84 to 1.73) |
4th quartile (14–30) | 1678 | 1061 | 1.96 (1.68 to 2.28) | 104 | 567 | 1.34 (0.92 to 1.94) |
Ever/never drank alcohol¶ p=0.123‡ | Ever drank alcohol | Never drank alcohol | ||||
1st quartile (49–78) | 596 | 1758 | 1 | 40 | 142 | 1 |
2nd quartile (40–48) | 1254 | 1761 | 1.59 (1.39 to 1.82) | 64 | 196 | 0.92 (0.55 to 1.52) |
3rd quartile (31–39) | 2002 | 1667 | 1.85 (1.61 to 2.12) | 80 | 174 | 1.29 (0.77 to 2.14) |
4th quartile (14–30) | 1642 | 1316 | 1.89 (1.64 to 2.19) | 140 | 312 | 1.57 (0.95 to 2.61) |
Ever/never manual p=0.231‡ | Ever worked in manual job | Never worked in manual job | ||||
1st quartile (49–78) | 335 | 800 | 1 | 301 | 1100 | 1 |
2nd quartile (40–48) | 1083 | 1502 | 1.40 (1.17 to 1.66) | 235 | 455 | 1.34 (1.05 to 1.72) |
3rd quartile (31–39) | 2040 | 1748 | 1.67 (1.41 to 1.97) | 42 | 93 | 1.06 (0.66 to 1.71) |
4th quartile (14–30) | 1759 | 1592 | 1.73 (1.45 to 2.06) | 23 | 36 | 1.47 (0.77 to 2.81) |
Tumour subsite | Cases | Controls | OR (95% CI)† | Cases | Controls | OR (95% CI)† | Cases | Controls | OR (95% CI)† | Cases | Controls | OR (95% CI)† |
Oral cavity | Oropharynx | Hypopharynx | Larynx | |||||||||
B | ||||||||||||
1st quartile (49–78) | 134 | 1900 | 1.00 | 166 | 1900 | 1 | 73 | 1900 | 1 | 223 | 1900 | 1 |
2nd quartile (40–48) | 270 | 1957 | 1.53 (1.21 to 1.94) | 288 | 1957 | 1.38 (1.11 to 1.72) | 181 | 1957 | 1.91 (1.41 to 2.59) | 480 | 1957 | 1.61 (1.33 to 1.96) |
3rd quartile (31–39) | 401 | 1841 | 1.84 (1.45 to 2.33) | 430 | 1841 | 1.67 (1.34 to 2.08) | 297 | 1841 | 2.29 (1.70 to 3.08) | 791 | 1841 | 1.94 (1.60 to 2.35) |
4th quartile (14–30) | 334 | 1628 | 1.63 (1.27 to 2.09) | 397 | 1628 | 1.68 (1.34 to 2.11) | 276 | 1628 | 2.61 (1.92 to 3.55) | 609 | 1628 | 1.96 (1.60 to 2.42) |
Combining ever/never smoking and drinking** p=0.052‡ | Ever smoked cigarettes, ever drank alcohol | Ever smoked cigarettes, never drank alcohol | Never smoked cigarettes, ever drank alcohol | Never smoked cigarettes, never drank alcohol | ||||||||
1st quartile (49–78) | 539 | 1109 | 1 | 22 | 66 | 1 | 57 | 649 | 1 | 18 | 76 | 1 |
2nd quartile (40–48) | 1164 | 1173 | 1.58 (1.36 to 1.83) | 48 | 98 | 1.30 (0.67 to 2.52) | 90 | 588 | 1.56 (1.08 to 2.25) | 16 | 98 | 0.53 (0.24 to 1.19) |
3rd quartile (31–39) | 1938 | 1240 | 1.88 (1.63 to 2.18) | 66 | 80 | 2.02 (1.05 to 3.90) | 64 | 427 | 1.41 (0.94 to 2.12) | 14 | 94 | 0.59 (0.25 to 1.39) |
4th quartile (14–30) | 1568 | 934 | 1.91 (1.63 to 2.23) | 110 | 127 | 2.57 (1.32 to 5.01) | 74 | 382 | 1.63 (1.07 to 2.48) | 30 | 185 | 0.54 (0.23 to 1.23) |
*Longest job, categories based on quartiles of control distribution.
†ORs and 95% CIs adjusted for sex, age, study centre, cigarette smoking (status, duration, cigarettes/day, pack-years), alcohol consumption (ever/never, drinks/day), an interaction term drinks/day×duration cigarette smoking) and worked ≥10 years in risk occupations (10 years before study).
‡Test of interaction between stratification factor and SIOPS.
§Categories separately for SIOPS distribution in control groups for men (m) and women (w).
¶Ever/never drank >15.6 mL of ethanol.
**Ever/never smoked ≥100 cigarettes in lifetime and ever/never drank alcohol (>15.6 mL of ethanol).
SIOPS, Standard International Occupational Prestige Scale.