Table 2

COVID-19-related symptoms since the start of the epidemic among all participants in the PICO-study reporting symptoms (n=3147), first round of inclusion

		SARS-CoV-2 seronegative n=3073		SARS-CoV-2 seropositive n=74		Total n=3147
		n	%	n	%	n	%	P value*
Meets COVID-19 case definition								<0.0001
	Yes	1096	35.7	55	74.3	1151	36.6
	No	1977	64.3	14	25.7	1996	63.4
Meets COVID-19 case definition, and self-reported to have had anosmia and/or ageusia								<0.0001
	Yes	1113	36.2	59	79.7	1172	37.2
	No	1960	63.8	15	20.3	1975	62.8
Developed symptoms since the start of the epidemic								<0.0001
	Yes	1903	61.9	69	93.2	1972	62.7
	No	1170	38.1	5	6.8	1175	37.3
General symptoms (one or more)		1350	43.9	62	83.8	1412	44.9	<0.0001
	Fever	361	11.8	32	43.2	393	12.5	<0.0001
	General malaise	332	10.8	34	46.0	366	11.6	<0.0001
	Headache	1001	32.6	48	64.9	1049	33.3	<0.0001
	Irritable/confused	232	7.6	17	23.0	249	7.9	<0.0001
	Muscle ache	312	10.5	22	29.7	334	10.6	<0.0001
	Arthralgia	497	16.2	42	56.8	539	17.1	<0.0001
	Anosmia and/or ageusia	111	3.6	39	52.7	150	4.8	<0.0001
Respiratory symptoms (one or more)		1622	52.8	64	86.5	1686	53.6	<0.0001
	Cough	905	29.5	45	60.8	950	30.2	<0.0001
	Sore throat	798	26.0	33	44.6	831	26.4	0.0003
	Runny nose	1128	36.7	45	60.8	1173	37.3	<0.0001
	Solely a runny nose & hay fever	22	0.7	1	1.4	23	0.7	0.42†
	Dyspnoea	251	8.2	13	17.6	264	8.4	0.004
Gastrointestinal symptoms (one or more)		668	21.7	32	43.2	700	22.2	<0.0001
	Diarrhoea	388	12.6	18	24.3	406	12.9	0.003
	Nausea/vomiting	207	6.7	13	17.6	220	7.0	0.0003
	Stomach ache	364	11.9	13	17.6	377	12.0	0.13

*p values were calculated with Pearson’s χ² Test, unless depicted otherwise.
†p value was calculated with Fisher’s Exact Test.
Missing values for all symptoms: 60.