Parental alcohol misuse (ages 0–19) in relation to the risk of alcohol misuse in adulthood (ages 20–63). Results from Cox regression analysis with four-way decomposition by school performance in grade 9 (age 16). Based on Sample B (n=13 021)
| Alcohol misuse in adulthood (ages 20–63) | ||||||
|---|---|---|---|---|---|---|
| Model 1* | Model 2† | |||||
| Estimate | P value | 95% CI | Estimate | P value | 95% CI | |
| Parental alcohol misuse (ages 0–19) | ||||||
| Total excess relative risk (tereri) | 1.54 | 0.000 | 0.92, 2.17 | 1.49 | 0.000 | 0.77, 2.20 |
| Four-way decomposition by school performance in grade 9 (age 16) | ||||||
| Excess relative risk due to neither mediation nor interaction (ereri_cde) | 0.12 | 0.011 | 0.25, 1.99 | 1.23 | 0.016 | 0.23, 2.23 |
| Excess relative risk due to interaction only (ereri_intref) | 0.19 | 0.511 | −0.38, 0.76 | 0.11 | 0.577 | −0.28, 0.49 |
| Excess relative risk due to mediated interaction (ereri_intmed) | 0.08 | 0.511 | −0.15, 0.31 | 0.05 | 0.579 | −0.11, 0.20 |
| Excess relative risk due to mediation only (ereri_pie) | 0.16 | 0.000 | 0.11, 0.20 | 0.10 | 0.000 | 0.06, 0.15 |
| Total effect relative risk ratio (tereria) | 2.54 | 0.000 | 1.92, 3.17 | 2.49 | 0.000 | 1.77, 3.20 |
| Four-way decomposition by school performance in grade 9 (age 16) | ||||||
| Proportion due to neither mediation nor interaction (p_cde) | 0.73 | 0.004 | 0.23, 1.22 | 0.83 | 0.000 | 0.43, 1.22 |
| Proportion due to interaction only (p_intref) | 0.12 | 0.499 | −0.23, 0.48 | 0.07 | 0.594 | −0.20, 0.34 |
| Proportion due to mediated interaction (p_intmed) | 0.05 | 0.500 | −0.09, 0.19 | 0.03 | 0.595 | −0.08, 0.14 |
| Proportion due to mediation only (p_pie) | 0.10 | 0.000 | 0.05, 0.15 | 0.07 | 0.001 | 0.03, 0.11 |
| Overall proportion due to mediation (op_m) | 0.15 | 0.042 | 0.01, 0.30 | 0.10 | 0.133 | −0.03, 0.23 |
| Overall proportion due to interaction (op_ati) | 0.17 | 0.499 | −0.33, 0.67 | 0.10 | 0.594 | −0.28, 0.48 |
| Overall proportion eliminated (op_e) | 0.27 | 0.279 | −0.22, 0.77 | 0.17 | 0.390 | −0.22, 0.57 |
*Unadjusted.
†Adjusted for gender, parental social class, parental educational level and parental income.
Component names, as specified in the med4way output, are presented in the table as italicised.