Table 3

Parental alcohol misuse (ages 0–19) in relation to the risk of alcohol misuse in adulthood (ages 20–63). Results from Cox regression analysis with four-way decomposition by school performance in grade 6 (age 13). Based on Sample A (n=13 752)

Alcohol misuse in adulthood (ages 20–63)
Model 1*Model 2†
EstimateP value95% CIEstimateP value95% CI
Parental alcohol misuse (ages 0–19)
Total excess relative risk (tereri)1.760.0001.17, 2.341.440.0000.84, 2.04
 Four-way decomposition by school performance in grade 6 (age 13)
  Excess relative risk due to neither mediation nor interaction (ereri_cde)0.760.0320.17, 2.340.790.0500.00, 1.58
  Excess relative risk due to interaction only (ereri_intref)0.740.0250.07, 1.420.320.0410.01, 0.62
  Excess relative risk due to mediated interaction (ereri_intmed)0.510.0260.07, 0.960.190.0460.04, 0.38
  Excess relative risk due to mediation only (ereri_pie)0.290.0000.03, 0.540.140.0000.09, 0.18
Total effect relative risk ratio (tereria)2.760.0002.17, 3.342.440.0001.84, 3.04
 Four-way decomposition by school performance in grade 6 (age 13)
  Proportion due to neither mediation nor interaction (p_cde)0.420.0190.07, 0.760.550.0070.15, 0.95
  Proportion due to interaction only (p_intref)0.290.0120.06, 0.520.220.067−0.02, 0.46
  Proportion due to mediated interaction (p_intmed)0.160.0130.03, 0.290.130.070−0.01, 0.28
  Proportion due to mediation only (p_pie)0.120.0000.07, 0.170.100.0000.05, 0.14
  Overall proportion due to mediation (op_m)0.280.0000.15, 0.420.230.0070.06, 0.40
  Overall proportion due to interaction (op_ati)0.460.0120.10, 0.810.360.067−0.02, 0.73
  Overall proportion eliminated (op_e)0.580.0010.22, 0.930.450.0260.05, 0.85
  • *Unadjusted.

  • †Adjusted for gender, parental social class, parental educational level and parental income.

  • Component names, as specified in the med4way output, are presented in the table as italicised.