Table 3

HRs (95% CI) of death from all causes according to standardised scores on attitudes to ageing scales at age 72 years, adjusted for accelerated DNA methylation GrimAge (AgeAccelGrim) and covariates (N=715)

Adjustments	Physical change	†p/p^FDR	Psychosocial loss	†p/p^FDR	Psychological growth	†p/p^FDR
Age and sex	0.66 (0.56 to 0.78)	<0.001/0.0003	1.28 (1.09 to 1.50)	0.002/0.004	0.87 (0.74 to 1.02)	0.089/0.120
Age, sex and AgeAccelGrim	0.71 (0.61 to 0.84)	<0.001/0.0003	1.23 (1.05 to 1.44)	0.0011/0.020	0.89 (0.75 to 1.03)	0.110/0.140
Age, sex, education and social class	0.67 (0.57 to 0.79)	<0.001/0.0003	1.25 (1.07 to 1.47)	0.005/0.009	0.84 (0.72 to 0.99)	0.040/0.064
Age, sex, education and social class plus AgeAccelGrim	0.72 (0.62 to 0.85)	<0.001/0.0003	1.21 (1.03 to 1.42)	0.020/0.033	0.86 (0.73 to 1.01)	0.065/0.097
Age, sex, smoking and alcohol	0.69 (0.58 to 0.81)	<0.001/0.0003	1.23 (1.05 to 1.44)	0.011/0.020	0.87 (0.74 to 1.02)	0.088/0.119
Age, sex, smoking and alcohol plus AgeAccelGrim	0.71 (0.60 to 0.83)	<0.001/0.0003	1.22 (1.04 to 1.42)	0.016/0.029	0.86 (0.75 to 1.01)	0.068/0.100
Age, sex, chronic disease and walking speed	0.73 (0.61 to 0.86)	<0.001/.0003	1.18 (1.01 to 1.39)	0.043/0.067	0.87 (0.75 to 1.02)	0.092/0.121
Age, sex, chronic disease plus AgeAccelGrim	0.76 (0.64 to 0.91)	0.001/0.002	1.16 (0.99 to 1.37)	0.075/0.106	0.88 (0.76 to 1.04)	0.138/0.168
Age, sex, anxiety and depression	0.67 (0.56 0.80)	<0.001/0.003	1.25 (1.03 to 1.51)	0.021/0.034	0.90 (0.77 to 1.07)	0.233/0.244
Age, sex, anxiety and depression plus AgeAccelGrim	0.72 (0.60 to 0.86)	<0.001/0.003	1.21 (1.00 to 1.45)	0.048/0.074	0.90 (0.77 to 1.06)	0.225/0.240
All*	0.76 (0.64 to 0.91)	0.002/0.004	1.15 (0.96 to 1.39)	0.128/0.159	0.87 (0.74 to 1.03)	0.104/0.135

*Age, sex, AgeAccelGrim, educational attainment, social class, total number of chronic diseases, time taken to walk 6 metres, smoking status, frequency of alcohol consumption, HADS anxiety score, HADS depression score.
†p^FDR is the p value corrected for multiple comparisons using the False Discovery Rate.
HADS, Hospital Anxiety and Depression Scale.