Table 2

Regression coefficients (95% CI) of ageing biomarkers according to standardised scores on attitudes to ageing scales at age 72 years

Attitudes to ageing scales, per SDLeucocyte telomere length* (n=758)Accelerated DNA methylation GrimAge† (n=715)Brain-predicted age difference (n=622)
Physical change
 Adjusted for age and sex−0.003 (−0.009 to 0.003) p=0.272; pFDR=0.637−0.725 (−1.03 to –0.418) p<0.001; pFDR=0.001−0.871 (−1.513 to –0.229) p=0.008; pFDR=0.062
 Adjusted for age, sex, education and social class−0.003 (−0.009 to 0.003) p=0.287; pFDR=0.637−0.689 (−1.00 to –0.380) p<0.001; pFDR=0.001−0.894 (−1.538 to –0.225) p=0.007; pFDR=0.062
 Adjusted for age, sex, smoking and alcohol−0.004 (−0.009 to 0.002) p=0.220; pFDR=0.625−0.467 (−0.721 to –0.211) p<0.001; pFDR=0.001−0.804 (−1.45 to –0.159) p=0.015; pFDR=0.101
 Adjusted for age, sex, chronic disease and walking speed−0.003 (−0.009 to 0.003) p=0.387; pFDR=0.756−0.520 (−0.842 to –0.197) p=0.002; pFDR=0.021−0.657 (−1.323 to –0.010) p=0.054; pFDR=0.224
 Adjusted for age, sex, anxiety and depression symptoms−0.004 (−0.001 to 0.003) p=0.255; pFDR=0.637−0.703 (−1.03 to –0.373) p<0.001; pFDR=0.001−0.672 (−1.346 to 0.001) p=0.050; pFDR=0.224
 Multivariable-adjusted‡−0.004 (−0.010 to 0.003) p=0.287; pFDR=0.637−0.289 (−0.568 to –0.010) p=0.042; pFDR=0.206−0.456 (−1.15 to 0.240) p=0.199; pFDR=0.625
Psychosocial loss
 Adjusted for age and sex0.001 (−0.005 to 0.006) p=0.838; pFDR=0.9350.370 (0.055 to 0.684) p=0.021; pFDR=0.1260.127 (−0.514 to 0.768) p=0.697; pFDR=0.867
 Adjusted for age, sex, education and social class0.001 (−0.005 to 0.006) p=0.862; pFDR=0.9350.335 (0.021 to 0.648) p=0.036; pFDR=0.1940.156 (−0.488 to 0.801) p=0.634; pFDR=0.867
 Adjusted for age, sex, smoking and alcohol0.001 (−0.005 to 0.006) p=0.775; pFDR=0.9300.098 (−0.162 to 0.358) p=0.460; pFDR=0.8030.059 (−0.588 to 0.705) p=0.858; pFDR=0.934
 Adjusted for age, sex, chronic disease and walking speed0.001 (−0.006 to 0.006) p=0.937; pFDR=0.9550.215 (−0.101 to 0.531) p=0.181; pFDR=0.611−0.055 (−0.703 to 0.593) p=0.869; pFDR=0.935
 Adjusted for age, sex, anxiety and depression symptoms0.001 (−0,007 to 0.007) p=0.883; pFDR=0.9350.325 (−0.039 to 0.689) p=0.080; pFDR=0.309−0.260 (−0.984 to 0.465) p=0.482; pFDR=0.803
 Multivariable-adjusted‡0.001 (−0.006 to 0.007) p=0.876; pFDR=0.935−0.010 (−0.308 to 0.282) p=0.931; pFDR=0.955−0.389 (−1.119 to 0.340 p=0.295; pFDR=0.637
Psychological growth
 Adjusted for age and sex−0.001 (−0.007 to 0.004) p=0.642; pFDR=0.868−0.072 (−0.385 to 0.240) p=0.707; pFDR=0.867−0.439 (−1.13 to 0.250) p=0.212; pFDR=0.625
 Adjusted for age, sex, education and social class−0.002 (−0.007 to 0.004) p=0.602; pFDR=0.868−0.129 (−0.441 to 0.182) p=0.417; pFDR=0.776−0.421 (−1.11 to 0.272) p=0.234; pFDR=0.632
 Adjusted for age, sex, smoking and alcohol−0.002 (−0.008 to 0.004) p=0.491; pFDR=0.8030.113 (−0.146 to 0.371) p=0.392; pFDR=0.756−0.352 (−1.05 to 0.343) p=0.320; pFDR=0.665
 Adjusted for age, sex, chronic disease and walking speed−0.001 (−0.007 to 0.004) p=0.678; pFDR=0.868−0.069 (−0.376 to 0.239) p=0.662; pFDR=0.868−0.473 (−1.16 to 0.213) p=0.176; pFDR=0.610
 Adjusted for age, sex, anxiety and depression symptoms−0.001 (−0.007 to 0.004) p=0.646; pFDR=0.8680.003 (−0.317 to 0.323) p=0.986; pFDR=0.986−0.219 (-0.925, 0.487) p=0.543; pFDR=0.837
 Multivariable-adjusted‡−0.002 (−0.008 to 0.004) p=0.490; pFDR=0.803−0.075 (−0.188 to 0.338) p=0.575; pFDR=0.827−0.191 (-0.906 to 0.525) p=0.601; pFDR=0.868
  • *All analyses of leucocyte telomere length were also adjusted for white blood cell counts.

  • †All analyses of accelerated DNA methylation GrimAge were adjusted for white blood cell counts.

  • ‡Adjusted for age, sex, educational attainment, social class, total number of chronic diseases, smoking status, frequency of alcohol consumption, time taken to walk 6 metres, HADS anxiety score, HADS depression score.

  • §pFDR is the p value corrected for multiple comparisons using the False Discovery Rate.

  • HADS, Hospital Anxiety and Depression Scale.