Subject characteristics at 20 year follow-up according to GBTM physical activity trajectories (n=3231)
| Characteristic | Low decreasing (n=733) | Light stable (n=1649) | Moderate increasing (n=849) | All (n=3231) |
| Age, years (mean ± SD) | 69.4 (5.6) | 68.5 (5.6) | 67.8 (5.1) | 68.5 (5.5) |
| Manual occupation (%, n)* | 59.8 (438) | 55.6 (916) | 38.5 (327) | 52.0 (1681) |
| Alcohol consumption, ≥light† (%, n) | 54.6 (400) | 62.4 (1029) | 73.5 (591) | 63.5 (1178) |
| Current smoker (%, n) | 19.5 (143) | 10.6 (174) | 7.4 (63) | 11.8 (380) |
| Married (%, n) | 80.5 (590) | 85.0 (1402) | 86.9 (738) | 84.5 (2730) |
| Resident in southern England (%, n)* | 26.2 (192) | 36.2 (597) | 38.2 (324) | 34.5 (1113) |
| Waist circumference, cm (mean±SD) | 100.1 (11.2) | 96.4 (10.0) | 95.4 (9.5) | 97.0 (10.3) |
| LDL, mmol/L (mean±SD) | 3.8 (1.0) | 4.0 (1.0) | 3.9 (0.9) | 3.9 (1.0) |
| HDL, mmol/L (mean±SD) | 1.3 (0.3) | 1.3 (0.3) | 1.4 (0.3) | 1.3 (0.3) |
| Insulin, μ/mL (median, IQR) | 9.6 (8.1) | 8.1 (5.9) | 7.5 (5.4) | 8.2 (6.4) |
| SBP, mm Hg (mean±SD) | 148.6 (23.9) | 149.0 (23.8) | 148.0 (24.4) | 148.6 (24.0) |
| FEV1, L‡ (mean±SD) | 235.2 (69.5) | 259.6 (62.5) | 276.1 (61.7) | 258.4 (65.5) |
| IL-6, pg/mL (median, IQR) | 2.8 (2.4) | 2.2 (1.8) | 2.0 (1.5) | 2.2 (1.9) |
| vWf, IU/dL (mean±SD) | 148.7 (48.4) | 137.1 (45.0) | 133.6 (43.0) | 138.8 (45.6) |
| Hs-TnT, pg/mL (median, IQR) | 12.7 (8.1) | 11.4 (7.0) | 11.5 (6.3) | 11.7 (7.0) |
| NT-proBNP, pg/mL (median, IQR) | 112.0 (206.0) | 88.0 (136.0) | 78.0 (111.0) | 89.0 (144) |
| Previous MI (%, n) | 9.1 (67) | 7.3 (120) | 6.0 (51) | 7.4 (238) |
| Previous stroke (%, n) | 3.3 (24) | 2.4 (39) | 2.2 (19) | 2.5 (82) |
| Previous diabetes (%, n) | 14.5 (106) | 7.4 (122) | 7.0 (59) | 8.9 (287) |
*Reported at baseline.
†light classified as ≥1 unit per week.
‡Standardised for height by multiplying FEV1 by the square of the mean population height (metres) divided by each participant’s height.
FEV1, forced expiratory volume in 1 s;GBTM, group-based trajectory modelling; HDL, high-density lipoprotein; Hs-TnT, high-sensitivity cardiac troponin T; IL-6, interleukin 6; LDL, low-density lipoprotein; MI, myocardial infarction; NT-proBNP, N-terminal pro-brain natriuretic peptide; SBP, systolic blood pressure; vWf, von Willebrand factor.