Changes in rates of hospital admissions for febrile and all seizures in England
| Age group (months) | Mean yearly rate of hospital admission (per 10 000) | Percentage reduction in hospital admissions post-vaccine introduction (95% CI)† | ||||
| Pre-rotavirus vaccination | Post-rotavirus vaccination (July 2013 to June 2017) | |||||
| Observed | Observed | Expected* | PCV7 | PCV 13 | RV | |
| All seizures | ||||||
| Hospital admissions for all seizures with any co-diagnosis | ||||||
| <12 | 108.6 | 107.8 | 104.9 | −2 (−8 to 3) | 1 (-7 to 9) | −4 (−8 to 0) |
| 12–23 | 180.7 | 144.8 | 153.1 | 5 (−1 to 11) | 13 (5 to 21) | 7 (2 to 12) |
| 24–59 | 75.2 | 71.8 | 75.1 | 1 (−7 to 8) | 4 (−7 to 14) | 4 (−2 to 9) |
| 0–59 | 103.2 | 93.3 | 97.7 | 2 (−5 to 7) | 7 (−1 to 15) | 4 (0 to 8) |
| Hospital admissions for all seizures with AGE | ||||||
| <12 | 3.7 | 2.6 | 3.9 | −16 (−45 to 7) | −12 (−59 to 22) | 24 (7 to 39) |
| 12–23 | 8.5 | 5.6 | 9.8 | −13 (−31 to 4) | −12 (−41 to 12) | 33 (20 to 44) |
| 24–59 | 2.1 | 2.1 | 2.6 | −10 (−28 to 5) | −7 (−33 to 15) | 11 (−4 to 23) |
| 0–59 | 3.7 | 2.9 | 4.3 | −13 (−30 to 2) | −9 (−34 to 12) | 23 (11 to 33) |
| Hospital admissions for all seizures with pneumonia | ||||||
| <12 | 3.4 | 2.8 | 2.3 | −2 (−23 to 16) | −9 (−46 to 19) | −22 (−44 to −4) |
| 12–23 | 9.8 | 7 | 7 | 8 (−5 to 19) | 0 (−21 to 18) | 3 (−8 to 14) |
| 24–59 | 3.3 | 3.2 | 3.4 | −3 (−17 to 10) | −9 (−34 to 12) | 2 (−11 to 13) |
| 0–59 | 4.6 | 3.9 | 3.9 | 1 (−9 to 11) | −5 (−23 to 10) | −1 (−10 to 8) |
| Febrile seizures | ||||||
| Hospital admissions for febrile seizures with any co-diagnosis | ||||||
| <12 | 36.4 | 25.8 | 27 | 13 (5 to 21) | 20 (9 to 30) | 10 (4 to 16) |
| 12–23 | 119.3 | 80.3 | 86.2 | 5 (−3 to 13) | 16 (5 to 26) | 8 (2 to 14) |
| 24–59 | 31.6 | 22.1 | 24 | 4 (−10 to 16) | 12 (−7 to 27) | 8 (−2 to 18) |
| 0–59 | 50.2 | 34.4 | 37.6 | 5 (−5 to 14) | 15 (2 to 26) | 10 (2 to 16) |
| Hospital admissions for febrile seizures with AGE | ||||||
| <12 | 1.7 | 0.9 | 1.5 | −16 (−48 to 8) | −6 (−55 to 27) | 34 (16 to 48) |
| 12–23 | 4.7 | 2.2 | 4.1 | −29 (−54 to −8) | −22 (−59 to 7) | 33 (19 to 45) |
| 24–59 | 0.8 | 0.5 | 0.7 | −2 (−28 to 19) | 15 (−20 to 39) | 29 (12 to 43) |
| 0–59 | 1.8 | 0.9 | 1.6 | −21 (−42 to −2) | −8 (−38 to 16) | 31 (19 to 41) |
| Hospital admissions for febrile seizures with pneumonia | ||||||
| <12 | 1.8 | 1.3 | 1.1 | −17 (−50 to 9) | −40 (−104 to 3) | −27 (−59 to −1) |
| 12–23 | 7.5 | 4.7 | 4.6 | 7 (−8 to 19) | −1 (−25 to 18) | 1 (−13 to 13) |
| 24–59 | 1.7 | 1.2 | 1.2 | 9 (−10 to 25) | 6 (−26 to 29) | 8 (−8 to 22) |
| 0–59 | 2.9 | 1.9 | 1.9 | 3 (−10 to 15) | −3 (−25 to 14) | 1 (−10 to 11) |
*Expected in the absence of rotavirus vaccination.
†Percentage change is calculated as 1−incidence rate ratio.
PCV7, seven-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; RV, rotavirus vaccine.