Adjusted HRs for colorectal cancer by duration of diabetes*
| Colorectal cancer | Colon cancer | Rectal cancer | ||||
| No. events | HR (95% CI) | No. events | HR (95% CI) | No. events | HR (95% CI) | |
| Incident diabetes | 299 | 1.15 (0.96 to 1.38) | 186 | 1.24 (0.98 to 1.56) | 153 | 1.11 (0.86 to 1.43) |
| Diabetes | ||||||
| No diabetes | 2576 | 1.00 (0.96 to 1.07) | 1466 | 1.00 (0.94 to 1.09) | 1485 | 1.00 (0.94 to 1.09) |
| 0 to <2 years | 49 | 1.47 (1.10 to 2.28) | 30 | 1.66 (1.16 to 2.85) | 28 | 1.34 (0.89 to 2.49) |
| 2 to <5 years | 117 | 1.18 (0.94 to 1.67) | 71 | 1.25 (0.93 to 1.94) | 57 | 0.97 (0.69 to 1.63) |
| 5 to <10 years | 225 | 1.33 (1.13 to 1.69) | 139 | 1.43 (1.17 to 1.94) | 125 | 1.33 (1.07 to 1.85) |
| ≥10 years | 57 | 0.95 (0.78 to 1.28) | 39 | 0.89 (0.68 to 1.33) | 21 | 0.94 (0.72 to 1.42) |
| P for trend | 0.03 | 0.02 | 0.36 | |||
The HR for incident diabetes was also adjusted for prevalent diabetes. P for trend was calculated among participants with diabetes.
For previously diagnosed diabetes and incident diabetes, duration was calculated as the time interval between age of diabetes diagnosis and age at risk.
For screen-detected diabetes, duration was calculated as the time interval between age at baseline and age at risk.
Duration of diabetes was missing in 20 participants.
*Estimates were stratified by age-at-risk, sex and region and adjusted for age at baseline, education, smoking, alcohol, total physical activity and BMI.
BMI, body mass index.