Relationship trajectory and T3 CVD risk factor outcomes
| Mean (95% CI) | Mean difference compared with good relationship (95% CI) | ||||||
| CVD risk factor outcome | Good relationship (n=362) | Improving relationship (n=65) | Deteriorating relationship (n=73) | Poor relationship (n=120) | |||
| Cardiovascular | Age adjusted | Age adjusted | Age+confounders | Age adjusted | Age+confounders | Age adjusted | Age+confounders |
| Systolic BP (mm Hg) | 132.63 (131.24 to 134.02) | −2.72 (−6.20 to 0.75) | −2.75 (−6.26 to 0.75) | 1.06 (−2.25 to 4.37) | 1.42 (−1.92 to 4.76) | 1.39 (−1.32 to 4.11) | 1.14 (−1.59 to 3.88) |
| Diastolic BP (mm Hg) | 77.37 (76.44 to 78.30) | −2.05 (−4.38 to 0.28) | −2.24 (−4.59 to 0.11) | 2.64 (0.42 to 4.86)* | 2.74 (0.50 to 4.98)* | 1.05 (−0.77 to 2.87) | 0.83 (−1.00 to 2.66) |
| Resting heart rate (bpm) | 64.93 (63.86 to 65.99) | −2.49 (−5.15 to 0.18) | −2.39 (−5.07 to 0.30) | 1.74 (−0.80 to 4.27) | 1.62 (−0.94 to 4.18) | 0.48 (−1.60 to 2.56) | 0.30 (−1.80 to 2.40) |
| Anthropometric | |||||||
| BMI (kg/m2) | 27.36 (26.98 to 27.74) | −0.45 (−1.40 to 0.50) | −0.57 (−1.51 to 0.37) | 0.62 (−0.29 to 1.52) | 0.75 (−0.16 to 1.65) | 0.06 (−0.68 to 0.81) | −0.01 (−0.74 to 0.73) |
| ∆BMI (kg/m2) | 4.67 (2.98 to 6.37) | −1.02 (−1.67 to −0.37)** | −1.07 (−1.73 to −0.42)** | 0.46 (−0.16 to 1.08) | 0.53 (−0.09 to 1.15) | −0.11 (−0.62 to 0.40) | −0.16 (−0.67 to 0.34) |
| Lipids | |||||||
| Total cholesterol (mmol/L) | 5.18 (5.08 to 5.27) | −0.24 (−0.48 to −0.00)* | −0.24 (−0.48 to 0.01) | 0.05 (−0.18 to 0.28) | 0.05 (−0.18 to 0.29) | −0.02 (−0.21 to 0.16) | −0.04 (−0.23 to 0.15) |
| HDL (mmol/L) | 1.29 (1.26 to 1.32) | 0.01 (−0.05 to 0.08) | 0.03 (−0.04 to 0.09) | 0.00 (−0.06 to 0.07) | 0.00 (−0.06 to 0.07) | −0.01 (−0.06 to 0.05) | −0.00 (−0.06 to 0.05) |
| LDL (mmol/L) | 3.26 (3.17 to 3.34) | −0.26 (−0.47 to −0.04)* | −0.25 (−0.46 to −0.03)* | −0.04 (−0.25 to 0.16) | −0.04 (−0.24 to 0.17) | −0.09 (−0.25 to 0.08) | −0.09 (−0.26 to 0.07) |
| Triglycerides (mmol/L) | 1.39 (1.33 to 1.45) | −0.11 (−0.27 to 0.05) | −0.12 (−0.29 to 0.04) | 0.09 (−0.06 to 0.24) | 0.10 (−0.06 to 0.25) | 0.04 (−0.08 to 0.17) | 0.03 (−0.09 to 0.16) |
| Glucose (mmol/L) | 5.61 (5.49 to 5.73) | 0.21 (−0.09 to 0.51) | 0.19 (−0.11 to 0.49) | 0.23 (−0.05 to 0.51) | 0.23 (−0.05 to 0.52) | 0.12 (−0.12 to 0.35) | 0.09 (−0.14 to 0.33) |
Regression model 1: outcome adjusted for age.
Regression model 2: outcome adjusted for age +confounders (housing tenure +financial difficulties+highest educational qualification +height).
*p = 0.01–0.05 **p=0.001– 0.01 ***p<0.001.
BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein.