Table 2

Unadjusted means of cardiovascular risk factors at age 44/45 years by age at first birth in the NCDS

Age at first birth
<20 years20–24 years25–29 years30–34 years>34 years
Mean (95% CI)Mean (95% CI)Mean (95% CI)Mean (95% CI)Mean (95% CI)p Trend
BMI
 Men29.45 (28.65 to 30.24)28.22 (27.95 to 28.49)27.83 (27.61 to 28.06)27.66 (27.37 to 27.96)27.24 (26.88 to 27.60)<0.001
 Women27.96 (27.44 to 28.49)27.61 (27.32 to 27.90)26.51 (26.21 to 26.81)25.89 (25.44 to 26.33)25.58 (25.02 to 26.14)<0.001
Waist:hip ratio
 Men0.95 (0.94 to 0.96)0.94 (0.93 to 0.94)0.93 (0.92 to 0.93)0.93 (0.92 to 0.93)0.92 (0.91 to 0.92)<0.001
 Women0.83 (0.82 to 0.83)0.82 (0.81 to 0.82)0.81 (0.80 to 0.81)0.80 (0.80 to 0.81)0.80 (0.79 to 0.81)<0.001
SBP
 Men135.35 (132.62 to 138.07)132.67 (131.64 to 133.69)132.09 (131.23 to 132.95)131.80 (130.69 to 132.92)128.89 (127.71 to 130.06)<0.001
 Women121.50 (120.01 to 122.99)120.08 (119.20 to 120.97)118.88 (117.94 to 119.82)118.13 (116.77 to 119.48)116.38 (114.69 to 118.08)<0.001
DBP
 Men84.07 (82.19 to 85.94)81.92 (81.20 to 82.63)81.55 (80.95 to 82.15)81.58 (80.75 to 82.40)79.00 (78.14 to 79.87)<0.001
 Women76.24 (75.29 to 77.19)75.13 (74.55 to 75.70)74.42 (73.79 to 75.05)74.37 (73.44 to 75.31)73.06 (71.94 to 74.17)<0.001
Total cholesterol
 Men6.11 (5.90 to 6.32)6.09 (6.01 to 6.18)6.06 (6.00 to 6.13)6.08 (5.98 to 6.17)5.99 (5.90 to 6.09)0.163
 Women5.81 (5.71 to 5.76)5.70 (5.64 to 5.76)5.65 (5.59 to 5.72)5.60 (5.51 to 5.70)5.62 (5.50 to 5.74)0.003
LDL cholesterol
 Men3.68 (3.49 to 3.87)3.56 (3.49 to 3.63)3.55 (3.49 to 3.61)3.58 (3.50 to 3.66)3.54 (3.46 to 3.61)0.459
 Women3.36 (3.28 to 3.44)3.32 (3.28 to 3.37)3.27 (3.21 to 3.33)3.16 (3.07 to 3.24)3.18 (3.08 to 3.29)<0.001
HDL cholesterol
 Men1.37 (1.31 to 1.42)1.41 (1.39 to 1.44)1.44 (1.42 to 1.46)1.44 (1.41 to 1.47)1.44 (1.41 to 1.47)0.042
 Women1.60 (1.57 to 1.64)1.64 (1.62 to 1.66)1.70 (1.67 to 1.73)1.77 (1.73 to 1.81)1.82 (1.76 to 1.87)<0.001
Triglycerides*
 Men2.30 (1.50 to 2.80)2.10 (1.40 to 3.10)2.10 (1.40 to 3.00)2.00 (1.40 to 3.10)2.00 (1.30 to 2.80)0.005
 Women1.50 (1.00 to 2.20)1.40 (1.00 to 2.00)1.30 (0.90 to 1.90)1.20 (0.90 to 1.70)1.20 (0.80 to 1.70)<0.001
HbA1c*
 Men5.20 (5.00 to 5.50)5.30 (5.00 to 5.50)5.20 (5.00 to 5.50)5.20 (5.00 to 5.50)5.20 (5.00 to 5.40)<0.001
 Women5.20 (5.00 to 5.40)5.10 (4.90 to 5.40)5.10 (4.90 to 5.30)5.10 (4.90 to 5.30)5.10 (4.90 to 5.30)<0.001
CRP*
 Men1.32 (0.72 to 2.56)1.09 (0.57 to 2.17)0.92 (0.47 to 1.79)0.84 (0.44 to 1.78)0.79 (0.44 to 1.55)<0.001
 Women1.33 (0.56 to 2.79)1.00 (0.47 to 2.41)0.84 (0.38 to 2.00)0.84 (0.38 to 1.96)0.73 (0.32 to 1.66)<0.001
Fibrinogen*
 Men2.95 (2.57 to 3.36)2.90 (2.63 to 3.45)2.82 (2.47 to 3.16)2.76 (2.44 to 3.16)2.71 (2.41 to 3.12)<0.001
 Women3.09 (2.70 to 3.54)3.01 (2.63 to 3.45)2.93 (2.58 to 3.31)2.85 (2.51 to 3.22)2.78 (2.45 to 3.17)<0.001
vWF*
 Men124 (94 to 149)122 (99 to 147)122 (95 to 151)113 (88 to 144)118 (94 to 148)0.031
 Women116 (94 to 144)118 (93 to 148)114 (91 to 144)109 (87 to 138)106 (87 to 136)<0.001
  • *Median (IQR) presented as outcome is positively skewed.

  • BMI, body mass index; CRP, C reactive protein; DBP, diastolic blood pressure; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NCDS, National Child Development Study; SBP, systolic blood pressure; vWF, von Willebrand Factor.