Table 1

Baseline characteristics for STEMI and NSTEMI, stratified by diabetes

STEMIp ValueNSTEMIp Value
Diabetes N=34 348No diabetes N=212 762Diabetes N=86 220No diabetes N=304 045
Demographics
 Mean (SD) age, years67.7 (12.78)65.3 (13.7)<0.00171.8 (11.7)70.8 (13.9)<0.001
 Male (%)23 135/ 34 241 (67.6%)150 910/211 965 (71.2%)<0.00154 166/86 051 (63.0%)190 451/303 403 (62.8%)0.071
 2003–20057086/34 348 (20.6%)44 735/212 762 (21.0%)<0.00117 614/86 220 (20.4%)70 999/304 045 (23.4%)<0.001
 2006–20089430/34 348 (27.5%)62 255/212 762 (29.3%)<0.00122 087/86 220 (25.6%)82 286/304 045 (27.1%)<0.001
 2009–201111 093/34 348 (32.3%)69 103/212 762 (32.5%)<0.00130 036/86 220 (34.8%)99 703/304 045 (32.8%)<0.001
 2012–20136739/34 348 (19.6%)36 669/212 762 (17.2%)<0.00116 483/86 220 (19.1%)51 057/304 045 (16.8%)<0.001
 Least deprived (1)4445/31 036 (14.3%)34 353/192 349 (17.9%)<0.00111 001/78 832 (14.0%)49 616/277 524 (17.9%)<0.001
 25528/31 036 (17.8%)38 667/192 349 (20.1%)<0.00114 070/78 832 (18.0%)57 068/277 524 (20.6%)<0.001
 36303/31 036 (20.3%)39 100/192 349 (20.3%)<0.00115 947/78 832 (20.2%)58 602/277 524 (21.1%)<0.001
 46761/31 036 (21.8%)39 090/192 349 (20.3%)<0.00117 556/78 832 (22.3%)56 181/277 524 (20.2%)<0.001
 Most deprived (5)7999/31 036 (25.8%)41 139/192 349 (21.4%)<0.00120 258/78 832 (25.7%)56 057/277 524 (20.2%)<0.001
 White (%)25 464/29 962 (74.1%)176 246/187 276 (94.1%)<0.00167 675/78 207 (86.5%)259 559/273 244 (95.0%)<0.001
Comorbidities
 Myocardial infarction*7190/34 348 (20.9%)22 791/212 762 (10.7%)<0.00130 124/86 220 (34.9%)68 478/304 045 (22.5%)<0.001
 Heart failure*1387/34 348 (4.0%)3413/212 762 (1.6%)<0.0019014/86 220 (10.5%)17 623/304 045 (5.8%)<0.001
 PCI*3084/34 348 (9.0%)9565/212 762 (4.5%)<0.00110 740/86 220 (12.5%)23 652/304 045 (7.8%)<0.001
 CABG*1625/34 348 (4.7%)4124/212 762 (1.9%)<0.0019947/86 220 (11.5%)18 227/304 045 (6.0%)<0.001
 Cerebrovascular disease*3039/34 348 (8.9%)9780/212 762 (4.6%)<0.00110 890/ 86 220 (12.6%)25 767/304 045 (8.5%)<0.001
 Peripheral vascular disease*1856/34 348 (5.4%)4978/212 762 (2.3%)<0.0017283/86 220 (8.5%)11 813/304 045 (3.9%)<0.001
 Chronic renal failure*1888/34 348 (5.5%)3736/212 762 (1.8%)<0.0019762/86 220 (11.3%)13 853/304 045 (4.6%)<0.001
 Hypertension*20 571/34 348 (59.9%)78 050/212 762 (36.7%)<0.00155 664/86 220 (64.6%)140 869/304 045 (46.3%)<0.001
 Asthma or COPD*3949/34 348 (11.5%)22 341/212 762 (10.5%)<0.00114 266/86 220 (16.6%)45 641/304 045 (15.0%)<0.001
 Family history of CHD*7495/ 34 348 (21.8%)54 398/212 762 (25.6%)<0.00115 990/ 86 220 (18.6%)64 382/ 304 045 (21.2%)<0.001
Risk factors
 Systolic BP, mean (SD) (mm Hg)135.0 (29.3)135.4 (28.6)0.02141.7 (29.0%)141.1 (28.6)<0.001
 Systolic BP, <90 mm Hg1676/34 348 (4.9%)8980/212 762 (4.2%)<0.0012138/86 220 (2.5%)7833/304 045 (2.6%)0.392
 Heart rate, mean (SD) bpm82.7 (22.6)77.9 (21.0)<0.00186.7 (23.7)82.3 (23.7)<0.001
 Heart rate, >110 bpm8630/34 348 (25.1%)45 606/212 762 (21.4%)<0.00121 264/86 220 (24.7%)65 914/304 045 (21.7%)<0.001
 Current/ex-smoker*19 444/34 348 (56.6%)136 148/212 762 (64.0%)<0.00147 152/86 220 (54.7%)174 297/304 045 (57.3%)0.111
 ST-segment deviation30 158/33 344 (90.5%)193 694/212 762 (93.5%)<0.00124 567/78 918 (31.1%)82 373/278 745 (29.6%)<0.001
 Cardiac arrest3972/33 166 (12.0%)23 366/212 762 (11.4%)0.0024121/ 83 257 (5.0%)12 487/292 759 (4.3%)<0.001
 Elevated cardiac enzymes29 955/31 501 (95.1%)186 244/212 762 (95.6%)<0.00177 641/84 291 (92.1%)274 666/296 784 (92.6%)<0.001
 Use of a loop diuretic8862/28 540 (31.1%)32 927/212 762 (18.5%)<0.00133 022/75 484 (43.8%)72 344/264 528 (27.4%)<0.001
Treatments
 Aspirin*25 153/29 261 (86.0%)164 393/188 095 (87.4%)<0.00161 684/71 784 (85.9%)221 713/258 175 (85.9%)<0.001
 β-blockers*6342/7303 (86.8%)44 503/50 692 (87.8%)<0.00112 431/14 771 (84.2%)47 020/56 113 (83.8%)<0.001
 Statin*25 076/29 516 (85.0%)163 584/189 165 (86.5%)<0.00162 248/73 784 (84.4%)216 923/262 075 (82.8%)0.073
 ACEi or ARB*6699/6967 (96.2%)47 220/ 48 742 (96.9%)<0.00113 408/14 361 (93.4%)48 891/53 285 (91.8%)<0.001
 Thienopyridine*12 458/34 211 (36.4*)78 469/ 212 197 (37.0%)<0.00129 488/85 690 (34.4%)98 003/ 302 474 (32.4%)<0.001
 Cardiac rehabilitation*24 349/32 153 (75.7%)162 226/202 825 (80.0%)<0.00155 548/78 923 (70.4%)204 571/ 280 308 (73.0%)<0.001
 Coronary angiography16 888/30 468 (55.4%)110 470/189 584 (58.3%)<0.00143 738/78 963 (55.4%)167 067/277 564 (60.2%)<0.001
 Reperfusion 22 971/31 423 (73.1%)156 207/197 631 (79.0%)<0.0012526/ 62 128 (4.1%)10 384/209 543 (5.0%)<0.001
 Care by a cardiology*21 982/34 348 (64.0%)143 928/246 911 (58.3%)<0.00153 532/86 220 (62.1%)181 124/336 441 (53.8%)<0.001
Admission ward
 Cardiac vs non-cardiac ward‡28 076/ 33 748 (83.2%)206 131/239 518 (86.1%)<0.00140 120/ 85 432 (47.0%)159 687/332 044 (48.1%)<0.001
 Timely reperfusion§ (≤90 min)20 565/ 21 157 (97.2%)164 424/167 335 (98.3%)<0.001
  • *Default imputed (we default imputed missing values as ‘no’ if the patient was eligible to receive the medication, but was not recorded as having received it).

  • ‡Cardiac ward: cardiac care unit, cardiac ward; non-cardiac ward: acute admission unit, general medical care, intensive therapy, other, died in A&E, step-down ward.

  • §Time to reperfusion defined as the time from hospital arrival to reperfusion.

  • ACEi/ARB, ACE inhibitors angiotensin receptor blocker; BP, blood pressure; CABG, coronary artery bypass graft; CAD, coronary artery disease; CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; PCI, percutaneous coronary intervention; PVD, peripheral vascular disease.