IRs* of cardiovascular morbidity and mortality events according to RHR group; the Tromsø Study 1994–2012
| RHR, bpm | |||||||
|---|---|---|---|---|---|---|---|
| <50 | 50–59 | 60–69 | 70–79 | 80–89 | 90–99 | ≥100 | |
| Men | |||||||
| MI | |||||||
| Events/person years | 10/3952 | 127/26 233 | 289/55 078 | 306/46 799 | 161/21 387 | 75/7645 | 28/3067 |
| Crude IR | 2.5 | 4.8 | 5.2 | 6.5 | 7.5 | 9.8 | 9.1 |
| Age-standardised IR (95% CI) | 2.2 (0.7 to 3.3) | 4.4 (3.7 to 5.1) | 5.1 (4.7 to 5.8) | 6.9 (6.2 to 8.0) | 7.7 (6.6 to 8.8) | 9.5 (7.3 to 11.7) | 8.4 (5.5 to 11.7) |
| AF | |||||||
| Events/person years | 30/4031 | 159/26 704 | 263/56 437 | 216/47 913 | 123/21 723 | 56/7720 | 16/3048 |
| Crude IR | 7.4 | 6.0 | 4.7 | 4.5 | 5.7 | 7.3 | 5.2 |
| Age-standardised IR (95% CI) | 5.5 (3.7 to 7.7) | 5.5 (4.4 to 6.2) | 4.7 (4.0 to 5.1) | 5.1 (4.4 to 5.5) | 5.8 (4.7 to 6.9) | 7.3 (5.5 to 9.1) | 4.7 (2.6 to 6.9) |
| Ischaemic stroke | |||||||
| Events/person years | 15/4157 | 77/27 249 | 175/56 950 | 168/48 150 | 73/22 130 | 28/7887 | 13/3150 |
| Crude IR | 3.6 | 2.8 | 3.1 | 3.5 | 3.3 | 3.5 | 4.1 |
| Age-standardised IR (95% CI) | 2.9 (1.5 to 4.4) | 2.6 (1.8 to 2.9) | 2.9 (2.6 to 3.7) | 4.0 (3.3 to 4.4) | 3.3 (2.6 to 4.0) | 3.7 (2.2 to 4.7) | 3.7 (1.8 to 5.8) |
| Total mortality | |||||||
| Events/person years | 36/4710 | 238/31 071 | 544/64 061 | 522/54 996 | 340/25 297 | 162/8863 | 76/3562 |
| Crude IR | 7.6 | 7.7 | 8.5 | 9.5 | 13.4 | 18.3 | 21.3 |
| Age-standardised IR (95% CI) | 5.5 (3.7 to 7.3) | 6.6 (5.8 to 7.7) | 8.4 (7.7 to 9.1) | 11.0 (9.9 to 11.7) | 13.9 (12.4 to 15.3) | 17.5 (15.0 to 20.5) | 18.6 (14.6 to 23.0) |
| Cardiovascular mortality | |||||||
| Events/person years | 14/4710 | 70/31 071 | 170/64 061 | 176/54 996 | 120/25 297 | 62/8863 | 22/3562 |
| Crude IR | 3.0 | 2.3 | 2.7 | 3.2 | 4.7 | 7.0 | 6.2 |
| Age-standardised IR (95% CI) | 2.2 (1.1 to 3.3) | 1.8 (1.5 to 2.6) | 2.6 (2.2 to 2.9) | 3.7 (3.3 to 4.4) | 5.1 (4.0 to 5.8) | 6.9 (5.1 to 8.4) | 5.5 (2.9 to 7.7) |
| Women | |||||||
| MI | |||||||
| Events/person years | 4/1245 | 31/16 143 | 135/54 388 | 185/62 732 | 133/35 480 | 52/11 871 | 40/5488 |
| Crude IR | 3.2 | 1.9 | 2.5 | 2.9 | 3.7 | 4.4 | 7.3 |
| Age standardised IR (95% CI) | 4.4 (0.0 to 8.4) | 1.8 (1.1 to 2.6) | 2.6 (2.2 to 2.9) | 2.9 (2.6 to 3.7) | 3.7 (3.3 to 4.4) | 4.0 (2.9 to 5.1) | 6.2 (4.4 to 8.0) |
| AF | |||||||
| Events/person years | 7/1250 | 49/16 095 | 174/54 303 | 210/62 764 | 136/35 498 | 46/11 849 | 27/5411 |
| Crude IR | 5.6 | 3.0 | 3.2 | 3.3 | 3.8 | 3.9 | 5.0 |
| Age-standardised IR (95% CI) | 4.7 (1.1 to 8.4) | 2.9 (2.2 to 4.0) | 3.3 (2.9 to 3.7) | 3.3 (2.9 to 4.0) | 4.0 (3.3 to 4.4) | 3.7 (2.6 to 4.7) | 4.4 (2.6 to 5.8) |
| Ischaemic stroke | |||||||
| Events/person years | 6/1288 | 28/16 238 | 108/54 681 | 119/63 251 | 91/35 763 | 44/11 961 | 21/5480 |
| Crude IR | 4.7 | 1.7 | 2.0 | 1.9 | 2.5 | 3.7 | 3.8 |
| Age-standardised IR (95% CI) | 4.4 (0.7 to 7.7) | 1.8 (1.1 to 2.2) | 2.2 (1.5 to 2.6) | 1.8 (1.5 to 2.2) | 2.6 (2.2 to 3.3) | 3.3 (2.6 to 4.4) | 3.3 (1.8 to 4.7) |
| Total mortality | |||||||
| Events/person years | 12/1402 | 121/18 217 | 437/62 350 | 571/70 922 | 380/39 775 | 175/13 513 | 100/6099 |
| Crude IR | 8.6 | 6.6 | 7.0 | 8.1 | 9.6 | 13.0 | 16.4 |
| Age-standardised IR (95% CI) | 7.3 (3.3 to 11.7) | 6.9 (5.5 to 8.0) | 7.3 (6.6 to 7.7) | 8.4 (7.7 to 9.1) | 9.5 (8.4 to 10.6) | 12.1 (10.2 to 13.9) | 13.9 (11.0 to 16.4) |
| Cardiovascular mortality | |||||||
| Events/person years | 8/1402 | 35/18 217 | 134/62 350 | 191/70 922 | 115/39 775 | 69/13 513 | 33/6099 |
| Crude IR | 5.7 | 1.9 | 2.1 | 2.7 | 2.9 | 5.1 | 5.4 |
| Age-standardised IR (95% CI) | 4.7 (1.5 to 8.0) | 2.2 (1.5 to 2.6) | 2.2 (1.8 to 2.6) | 2.9 (2.6 to 3.3) | 2.9 (2.2 to 3.3) | 4.7 (3.7 to 5.8) | 4.4 (2.9 to 5.8) |
*IR per 1000 person-years.
AF, atrial fibrillation; IR, incidence rate; MI, myocardial infarction; RHR, resting heart rate.