Subgroup analysis among 10 studies with OR of hospitalisation risk for frailty
| Subgroup | Number of studies | Pooled OR (95% CI) | p Value | I2 (%) | p For subgroup difference |
|---|---|---|---|---|---|
| Location* | |||||
| Europe | 5 | 1.85 (1.52 to 2.26) | <0.00 001 | 57 | 0.66 |
| USA | 3 | 1.95 (1.76 to 2.16) | <0.00001 | 74 | |
| Sample size | |||||
| n=4000+ | 5 | 1.85 (1.69 to 2.03) | <0.00001 | 65 | 0.06 |
| n<4000 | 5 | 2.57 (1.85 to 3.57) | <0.00001 | 11 | |
| Female proportion | |||||
| Female ≥60% | 5 | 1.91 (1.70 to 2.13) | <0.00001 | 69 | 0.88 |
| Female<60% | 5 | 1.88 (1.64 to 2.16) | <0.00001 | 40 | |
| Mean age† | |||||
| ≥75 | 3 | 3.09 (2.00 to 4.77) | <0.00001 | 29 | 0.02 |
| <75 | 6 | 1.77 (1.56 to 2.01) | <0.00001 | 52 | |
| Frailty criteria | |||||
| CHS | 7 | 1.93 (1.76 to 2.12) | <0.00001 | 65 | 0.25 |
| SOF | 3 | 1.64 (1.27 to 2.12) | 0.0002 | 0 | |
| Follow-up period | |||||
| >2 years | 5 | 1.84 (1.67 to 2.02) | <0.00001 | 24 | 0.14 |
| ≤2 years | 5 | 2.17 (1.77 to 2.65) | <0.00001 | 67 | |
| >1 years | 8 | 1.89 (1.73 to 2.07) | <0.00001 | 64 | 0.73 |
| ≤1 years | 2 | 2.11 (1.13 to 3.93) | 0.02 | 0 | |
| Outcome adjustment | |||||
| Adjusted | 6 | 1.84 (1.68 to 2.02) | <0.00001 | 66 | 0.05 |
| Unadjusted | 4 | 2.46 (1.87 to 3.24) | <0.00001 | 0 | |
*Two studies were from Korea and Mexico, respectively.
†One study did not provide mean age.
CHS, Cardiovascular Health Study; SOF, Study of Osteoporotic Fractures.