Table 4

Marginal and adjusted ORs demonstrating the association between adverse socioeconomic position under the accumulation of risk and social mobility frameworks with increased susceptibility to MS*

 Cases (%)Controls (%)UnadjustedConventional covariates†, census block SEP, HLA-DRB1*15:01, and wGRS
OR 95% CIpOR 95% CIp
Cumulative SEP score‡
 High29.537.711
 Medium39.036.51.361.05 to 1.770.0191.401.05 to 1.860.024
 Low31.425.81.551.17 to2.050.00201.501.09 to 2.050.012
 ptrend0.00170.011
Social mobility§
 High–high21.431.511
 High–low13.012.31.561.07 to 2.260.0201.541.02 to 2.330.042
 Low–high24.022.11.601.17 to 2.190.00311.521.07 to 2.150.019
 Low–low41.734.11.801.36 to 2.383.5×10−51.741.27 to 2.395.7×10−4
 ptrend2.9×10−59.8×10−4
  • *Analyses were restricted to MS cases with age of onset ≥28 years.

  • †Conventional covariates including year of birth, gender, family history of MS, ever smoker, ever having infectious mononucleosis and body size at age 20.

  • ‡Analyses used a cumulative SEP score that included both household education and participant's education. Score for each SEP measure was calculated separately and then summed (range 0–6). Household education: high school or less=0; less than a college degree=1; college degree=2, postgraduate degree=3. Participant's education: high school or less=0; less than a college degree=1; college degree=2, postgraduate degree=3. Low cumulative SEP score indicates a score of 0–1; medium, 2–3; and high, 4–6.

  • §Social mobility measures were as follows: parental education (high=college education or above; low=less than a college education); current education (high=college education or above; low=less than a college education).

  • MS, multiple sclerosis; SEP, socioeconomic position; wGRS, weighted genetic risk score.