Table 3 Sex-specific cross-site 1-year prevalence of substance use and abuse/dependence among offspring 12–17 by parent proband group
Parent proband group
Child interviewDrug abuse/dependenceAlcohol abuse/dependencePsychiatric disorderControlAll
Male n = 87Female n = 95Male n = 58Female n = 55Male n = 138Female n = 130Male n = 105Female n = 105Male n = 388Female n = 385TotalSex
Any behaviour Dx‡13.811.613.89.112.37.712.44.812.98.110.5M*
Substance use
Any substance55.149.548.338.244.935.433.328.644.637.441.0§
Nicotine use31.023.213.816.427.516.917.112.823.417.720.6M*
Alcohol use55.249.544.832.744.233.131.425.743.235.039.2§
Drug use16.014.715.510.913.88.55.77.612.410.111.3
Disorders
Any substance8.05.33.41.88.73.12.91.96.23.14.7M*
Alcohol4.64.21.70.06.50.81.00.02.81.32.6M*
Drug4.64.21.71.85.12.31.51.93.62.63.1
Child self-report(n = 87)(n = 93)(n = 57)(n = 55)(n = 139)(n = 129)(n = 107)(n = 103)
Substance use
Any use59.754.845.649.050.346.543.036.850.045.647.9
Nicotine33.325.817.516.427.315.517.816.524.718.221.5M*
Alcohol57.452.743.945.545.345.040.232.046.442.944.8
Marijuana17.214.010.510.910.83.98.48.732.28.610.1M†
  • *p<0.05; †p<0.10.

  • ‡Includes conduct disorder, attention deficit disorder, oppositional defiant disorder.

  • §Interaction between sex and proband group (p<0.05): significantly higher rates among male offspring of parents with psychiatric disorders in Puerto Rico vs New Haven.