Table 1 Classes of antiretrovirals with their respective Food Drug and Administration (FDA) market-approved year
Antiretrovirals before 1998Antiretrovirals since 1998
NRTINRTI
ddi (1991)Abacavir (1998)
ddC (1992)
d4T (1994)
Lamivudine (1995)
Zidovudine (1987)
Combivir (1997)
NNRTINNRTI
Delavirdine (1997)Efavirnez (1998)
Nevirapine (1997)
Protease inhibitorProtease inhibitor
Saquinavir (1995)Amprenavir (1999)
Ritonavir (1996)Lopinavir/Ritonavir (2000)
Nelfinavir (1997)
Indinavir (1996)
  • NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitors.