Hazard ratios for death from ischaemic heart disease, cerebrovascular disease, and occlusive stroke (95% CI) in 11474 men and women born 1915–1929. Adjusted for age, period of birth, sex, and social characteristics (mother’s civil status and social group when the study subject was born, and subject’s own social group, education, marital status, and household car ownership from 1960 census)
| Ischaemic heart disease | Cerebrovascular disease | Cerebrovascular disease: occlusive stroke | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Number of events | HR (95% CI) age, period, and sex adjusted | HR (95% CI) fully adjusted | Number of events | HR (95% CI) age, period, and sex adjusted | HR (95% CI) fully adjusted | Number of events | HR (95% CI) age, period, and sex adjusted | HR (95% CI) fully adjusted | |
| Total number of events 1960–2001 | 1211 | 355 | 127 | ||||||
| Weight for gestational age (quintiles) | |||||||||
| Lowest | 259 | 1.0 | 1.0 | 68 | 1.0 | 1.0 | 22 | 1.0 | 1.0 |
| 2nd | 242 | 0.83 (0.70,0.99) | 0.84 (0.71,1.00) | 84 | 1.06 (0.77,1.45) | 1.08 (0.78,1.49) | 29 | 1.09 (0.63,1.90) | 1.12 (0.64,1.96) |
| 3rd | 260 | 0.87 (0.73,1.03) | 0.92 (0.77,1.09) | 75 | 0.91 (0.66,1.27) | 0.95 (0.68,1.32) | 30 | 1.09 (0.63,1.90) | 1.16 (0.66,2.01) |
| 4th | 218 | 0.74 (0.62,0.89) | 0.77 (0.65,0.93) | 69 | 0.83 (0.60,1.17) | 0.87 (0.62,1.21) | 22 | 0.80 (0.44,1.45) | 0.86 (0.47,1.55) |
| Highest | 232 | 0.76 (0.63,0.90) | 0.80 (0.67,0.96) | 59 | 0.70 (0.50,1.00) | 0.74 (0.52,1.05) | 24 | 0.82 (0.46,1.48) | 0.89 (0.50,1.61) |
| p value heterog 4 df | 0.007 | 0.035 | 0.136 | 0.225 | 0.673 | 0.764 | |||
| p value linear trend | 0.001 | 0.010 | 0.015 | 0.035 | 0.266 | 0.421 | |||
| Gestational age (weeks) | |||||||||
| 30–35 | 52 | 1.0 | 1.0 | 23 | 1.0 | 1.0 | 15 | 1.0 | 1.0 |
| 36–37 | 108 | 0.92 (0.66,1.28) | 0.95 (0.68,1.32) | 39 | 0.72 (0.43,1.20) | 0.74 (0.44,1.25) | 13 | 0.37 (0.18,0.78) | 0.39 (0.18,0.82) |
| 38–39 | 395 | 0.94 (0.70,1.26) | 1.01 (0.75,1.35) | 122 | 0.62 (0.40,0.97) | 0.66 (0.42,1.03) | 37 | 0.29 (0.16,0.53) | 0.32 (0.17,0.58) |
| 40–41 | 509 | 1.01 (0.76,1.35) | 1.08 (0.81,1.44) | 133 | 0.56 (0.36,0.88) | 0.60 (0.38,0.94) | 50 | 0.32 (0.18,0.58) | 0.36 (0.20,0.65) |
| 42+ | 147 | 1.06 (0.77,1.45) | 1.09 (0.80,1.50) | 38 | 0.57 (0.34,0.96) | 0.60 (0.35,0.99) | 12 | 0.28 (0.13,0.59) | 0.29 (0.14,0.63) |
| p value heterog 4 df | 0.663 | 0.775 | 0.148 | 0.234 | 0.007 | 0.015 | |||
| p value linear trend | 0.227 | 0.160 | 0.021 | 0.031 | 0.009 | 0.016 | |||