Twenty year follow up in 7176 men, showing BMI (kg/m2) at screening (Q1) and risk of major CVD events and diabetes (rates/1000 person years and adjusted (+) relative risk). (+) Adjusted for age, social class, smoking, physical activity, alcohol intake, undiagnosed CHD, and lung function
| Normal <25 (3313) | Moderately overweight 25–27.5(2192) | Considerably overweight 27.5–29.9(1104) | Obese ⩾30(567) | Test for linear trend* | |
|---|---|---|---|---|---|
| SBP; systolic blood pressure; chol = total cholesterol. *Test for linear trend with BMI fitted as a continuous variable. | |||||
| Major CVD (1989) | |||||
| Number of cases | 786 | 621 | 364 | 218 | |
| Rates/1000 person years | 13.9 | 17.2 | 20.2 | 24.9 | |
| Adjusted (+) | 1.00 | 1.24 (1.11 to 1.38) | 1.41 (1.24 to 1.60) | 1.78 (1.52 to 2.08) | p<0.0001 |
| +SBP | 1.00 | 1.16 (1.04 to 1.30) | 1.29 (1.14 to 1.49) | 1.50 (1.28 to 1.75) | p<0.0001 |
| +SBP+chol | 1.00 | 1.11 (0.99 to 1.23) | 1.23 (1.08 to 1.40) | 1.41 (1.20 to 1.65) | p<0.0001 |
| Diabetes (449) | |||||
| Number of cases | 95 | 135 | 114 | 105 | |
| Rates/1000 person years | 1.6 | 3.5 | 5.9 | 11.4 | |
| Adjusted (+) | 1.00 | 2.41 (1.84 to 3.17) | 4.00 (3.02 to 5.30) | 7.49 (5.59 to 10.00) | p<0.0001 |
| +SBP | 1.00 | 2.27 (1.73 to 2.98) | 3.64 (2.74 to 4.83) | 6.30 (4.67 to 8.51) | p<0.0001 |
| +SBP+chol | 1.00 | 2.24 (1.71 to 2.94) | 3.57 (2.68 to 4.74) | 6.20 (4.58 to 8.38) | p<0.0001 |