Association between birth weight in offspring (F2) and type 2 diabetes in grandparents (F0)
| Birth weight tertile of baby (range (g)) | Number cases/non-cases | OR* (95% CI) | OR† (95% CI) |
|---|---|---|---|
| *Adjusted for sex and gestational age; †adjusted for sex, gestational age, square of gestational age, height of mother, smoking status of mother in mid-pregnancy, parity, ethnicity, and additionally for age of grandparent, and smoking in that relative. | |||
| Maternal grandmother | |||
| 1 (⩽3240) | 48/2669 | 1 | 1 |
| 2 (3241–3640) | 42/2821 | 1.00 (0.65 to 1.53) | 1.02 (0.68 to 1.55) |
| 3 (3641–5640) | 71/2827 | 1.77 (1.22 to 2.59) | 1.59 (1.09 to 2.33) |
| p for linear trend | 0.001 | <0.001 | |
| (non-linear) | (0.84) | (0.54) | |
| Maternal grandfather | |||
| 1 (⩽3240) | 54/2247 | 1 | 1 |
| 2 (3241–3640) | 70/2414 | 1.03 (0.72 to 1.50) | 1.03 (0.71 to 1.48) |
| 3 (3641–5640) | 83/2422 | 1.56 (1.11 to 2.18) | 1.59 (1.13 to 2.22) |
| p for linear trend | 0.004 | 0.005 | |
| (non-linear) | (0.58) | (0.18) | |
| Paternal grandmother | |||
| 1 (⩽3240) | 34/1709 | 1 | 1 |
| 2 (3241–3640) | 28/1741 | 1.03 (0.64 to 1.68) | 1.00 (0.62 to 1.63) |
| 3 (3641–5640) | 27/1780 | 0.67 (0.39 to 1.15) | 0.65 (0.38 to 1.12) |
| p for linear trend | 0.085 | 0.13 | |
| (non-linear) | (0.036) | (0.01) | |
| Paternal grandfather | |||
| 1 (⩽3240) | 41/1400 | 1 | 1 |
| 2 (3241–3640) | 45/1375 | 1.32 (0.86 to 2.03) | 1.50 (0.97 to 2.34) |
| 3 (3641–5640) | 31/1438 | 0.76 (0.46 to 1.23) | 0.92 (0.57 to 1.51) |
| p for linear trend | 0.27 | 0.77 | |
| (non-linear) | (0.026) | (0.16) | |