An association between a polymorphism in the GSTP1 gene and Parkinson’s disease is strongest in the subgroup of subjects exposed to pesticides8
| Exposure status | GSTP1 genotype at codon 105 | Parkinson’s disease cases | Controls | Odds ratio (p value)* |
|---|---|---|---|---|
| *p Values calculated using Woolf’s formula for the standard error of the log odds ratio.22 | ||||
| All subjects | Ile/Ile | 33 | 39 | |
| Ile/Val, Val/Val | 62 | 56 | 1.31 (p = 0.0.370) | |
| Subjects exposed to pesticides only | Ile/Ile | 7 | 14 | |
| Ile/Val, Val/Val | 32 | 12 | 5.33 (p = 0.004) | |