Table 2

Association of birth weight with CHD with adjustment for potential confounding and mediating factors

ModelNumber with complete dataAge and maternal survival adjusted OR for CHD per 1 SD (0.80 kg) increase in birth weight (95% CI)Fully adjusted OR for CHD per 1 SD (0.80 kg) increase in birth weight (95% CI)
*Indicators of childhood social circumstances: childhood occupational social class (entered as indicator variables: I, II, IIInon-manual, IIImanual, IV, V), childhood house with bathroom, childhood house with hot water, family access to car as a child (all binary variables); †all confounders: childhood and adulthood occupational social class (both entered as indicator variables: I, II, IIInon-manual, IIImanual, IV, V, VI), childhood house with bathroom, childhood house with hot water, family access to car as a child, car access as adult, living in local authority housing, no private or work pension (all binary variables), age at leaving full time education (split into thirds and entered as indicator variable) and smoking (never, past, and current—includes those who stopped in past six months, entered as indicator variable); ‡analysis among non-diabetics only; §components of insulin resistance syndrome: insulin resistance/diabetes (quarters of HOMA score with fifth category = diabetes, entered as an indicator variable), triglyceride concentrations (logged), waist to hip ratio (both entered as continuous variable), high density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure (all categorised into quarters and entered as indicator variables); ¶menopausal age categorised into quarters and entered as indicator variable.
Potential confounding factors
Indicators of childhood social circumastances*13870.84 (0.72 to 0.97)0.83 (0.71 to 0.96)
All confounding factors†13830.84 (0.72 to 0.97)0.84 (0.72 to 0.97)
Potential mediating factors
Insulin resistance (HOMA score)‡10830.82 (0.69 to 0.98)0.85 (0.72 to 1.01)
Insulin resistance/diabetes categories and other components insulin resistance syndrome§12460.82 (0.70 to 0.97)0.87 (0.72 to 1.03)
Menopausal age¶13420.83 (0.72 to 0.97)0.83 (0.71 to 0.97)