Adjusted relative rates of mortality and 95% confidence intervals by number of siblings in 5765 men aged 35–64 from the Collaborative study in 25 years of follow up
| Siblings | |||||||
|---|---|---|---|---|---|---|---|
| 0 | 1–2* | 3–4 | 5–6 | 7+ | Relative rate per sibling | Trend† | |
| *Baseline category. †Using siblings as a continuous variable. ‡Adjusted for age and smoking. §Adjusted for age, social class, father’s social class, car user, deprivation category, and education. ¶Adjusted for age, smoking, social class, father’s social class, car user, deprivation category, education, bronchitis, height, adjusted FEV1, systolic blood pressure, cholesterol, and units of alcohol. | |||||||
| All cause | |||||||
| Relative rate‡ | 0.84 (0.71 to 1.01) | 1 | 1.07 (0.96 to 1.19) | 1.17 (1.04 to 1.32) | 1.24 (1.10 to 1.41) | 1.04 (1.02 to 1.05) | p<0.0001 |
| Relative rate§ | 0.91 (0.76 to 1.09) | 1 | 1.01 (0.90 to 1.12) | 1.05 (0.93 to 1.19) | 1.07 (0.93 to 1.21) | 1.01 (0.99 to 1.03) | p=0.19 |
| Relative rate¶ | 0.87 (0.73 to 1.04) | 1 | 0.98 (0.88 to 1.10) | 1.01 (0.89 to 1.14) | 1.03 (0.90 to 1.18) | 1.01 (0.99 to 1.02) | p=0.35 |
| CHD | |||||||
| Relative rate‡ | 1.13 (0.86 to 1.47) | 1 | 1.18 (0.99 to 1.41) | 1.45 (1.20 to 1.76) | 1.26 (1.02 to 1.55) | 1.03 (1.01 to 1.06) | p=0.013 |
| Relative rate§ | 1.21 (0.93 to 1.58) | 1 | 1.11 (0.92 to 1.33) | 1.29 (1.06 to 1.57) | 1.08 (0.86 to 1.34) | 1.01 (0.98 to 1.03) | p=0.66 |
| Relative rate¶ | 1.20 (0.92 to 1.57) | 1 | 1.11 (0.92 to 1.32) | 1.28 (1.05 to 1.56) | 1.08 (0.87 to 1.35) | 1.01 (0.98 to 1.03) | p=0.58 |
| Stroke | |||||||
| Relative rate‡ | 0.45 (0.21 to 0.99) | 1 | 0.96 (0.67 to 1.38) | 1.07 (0.72 to 1.60) | 1.01 (0.65 to 1.55) | 1.03 (0.98 to 1.09) | p=0.25 |
| Relative rate§ | 0.50 (0.23 to 1.09) | 1 | 0.93 (0.64 to 1.35) | 1.01 (0.67 to 1.53) | 0.90 (0.57 to 1.42) | 1.01 (0.96 to 1.07) | p=0.64 |
| Relative rate¶ | 0.45 (0.20 to 0.98) | 1 | 0.90 (0.62 to 1.30) | 0.99 (0.65 to 1.50) | 0.88 (0.56 to 1.39) | 1.01 (0.96 to 1.07) | p=0.61 |
| Lung cancer | |||||||
| Relative rate‡ | 0.50 (0.27 to 0.93) | 1 | 1.02 (0.74 to 1.40) | 0.94 (0.65 to 1.36) | 1.51 (1.07 to 2.12) | 1.07 (1.02 to 1.11) | p=0.003 |
| Relative rate§ | 0.58 (0.31 to 1.10) | 1 | 0.94 (0.68 to 1.30) | 0.82 (0.56 to 1.20) | 1.20 (0.83 to 1.72) | 1.03 (0.98 to 1.08) | p=0.20 |
| Relative rate¶ | 0.51 (0.27 to 0.96) | 1 | 0.89 (0.64 to 1.22) | 0.74 (0.51 to 1.09) | 1.11 (0.77 to 1.60) | 1.03 (0.98 to 1.07) | p=0.30 |
| Other smoking related cancer | |||||||
| Relative rate‡ | 0.68 (0.29 to 1.62) | 1 | 1.13 (0.70 to 1.81) | 1.25 (0.74 to 2.13) | 1.20 (0.68 to 2.12) | 1.04 (0.97 to 1.11) | p=0.24 |
| Relative rate§ | 0.73 (0.31 to 1.74) | 1 | 1.06 (0.65 to 1.72) | 1.13 (0.65 to 1.95) | 1.04 (0.57 to 1.90) | 1.02 (0.95 to 1.10) | p=0.64 |
| Relative rate¶ | 0.69 (0.29 to 1.65) | 1 | 1.02 (0.63 to 1.66) | 1.09 (0.63 to 1.89) | 1.00 (0.54 to 1.82) | 1.01 (0.94 to 1.09) | p=0.71 |
| Stomach cancer | |||||||
| Relative rate‡ | 0.94 (0.27 to 3.29) | 1 | 1.97 (0.98 to 3.95) | 1.65 (0.74 to 3.72) | 2.95 (1.41 to 6.17) | 1.15 (1.06 to 1.25) | p=0.0006 |
| Relative rate§ | 0.98 (0.28 to 3.45) | 1 | 1.95 (0.96 to 3.95) | 1.63 (0.70 to 3.77) | 2.73 (1.24 to 6.00) | 1.14 (1.05 to 1.25) | p=0.003 |
| Relative rate¶ | 0.94 (0.27 to 3.29) | 1 | 1.91 (0.94 to 3.88) | 1.53 (0.66 to 3.54) | 2.66 (1.21 to 5.85) | 1.14 (1.04 to 1.24) | p=0.003 |
| Respiratory disease | |||||||
| Relative rate‡ | 0.68 (0.33 to 1.38) | 1 | 1.01 (0.68 to 1.50) | 1.26 (0.82 to 1.92) | 1.42 (0.92 to 2.19) | 1.05 (1.00 to 1.11) | p=0.07 |
| Relative rate§ | 0.78 (0.38 to 1.58) | 1 | 0.86 (0.58 to 1.29) | 0.97 (0.63 to 1.51) | 1.01 (0.64 to 1.59) | 1.00 (0.94 to 1.06) | p=0.97 |
| Relative rate¶ | 0.72 (0.35 to 1.47) | 1 | 0.79 (0.52 to 1.18) | 0.83 (0.54 to 1.30) | 0.81 (0.51 to 1.29) | 0.97 (0.92 to 1.03) | p=0.38 |