Table 3

Age adjusted relative rates of mortality and 95% confidence intervals by number of siblings in 5765 men aged 35–64 from the Collaborative study in 25 years of follow up

	Siblings
	0	1–2*	3–4	5–6	7+	Relative rate per sibling	Trend†
*Baseline category. †Using siblings as a continuous variable.
No of men	489	2043	1535	915	783
All cause
No of deaths	149	719	646	446	390
Relative rate	0.89 (0.75 to 1.07)	1	1.12 (1.00 to 1.24)	1.24 (1.10 to 1.40)	1.30 (1.15 to 1.47)	1.04 (1.02 to 1.06)	p<0.0001
CHD
No of deaths	69	251	246	190	136
Relative rate	1.18 (0.91 to 1.55)	1	1.22 (1.03 to 1.46)	1.52 (1.26 to 1.84)	1.31 (1.06 to 1.61)	1.04 (1.01 to 1.06)	p=0.005
Stroke
No of deaths	7	63	55	40	31
Relative rate	0.50 (0.23 to 1.08)	1	1.00 (0.69 to 1.44)	1.13 (0.76 to 1.69)	1.06 (0.69 to 1.63)	1.03 (0.98 to 1.09)	p=0.20
Lung cancer
No of deaths	11	83	73	43	56
Relative rate	0.57 (0.30 to 1.06)	1	1.11 (0.81 to 1.52)	1.06 (0.73 to 1.54)	1.65 (1.17 to 2.33)	1.08 (1.03 to 1.12)	p=0.0009
Other smoking related cancer
No of deaths	6	36	33	23	18
Relative rate	0.72 (0.30 to 1.70)	1	1.16 (0.72 to 1.87)	1.32 (0.78 to 2.23)	1.25 (0.71 to 2.20)	1.04 (0.98 to 1.12)	p=0.20
Stomach cancer
No of deaths	3	13	21	11	16
Relative rate	0.99 (0.28 to 3.46)	1	2.06 (1.03 to 4.12)	1.75 (0.78 to 3.94)	3.06 (1.46 to 6.40)	1.16 (1.07 to 1.25)	p=0.0004
Other cancer
No of deaths	20	108	62	38	40
Relative rate	0.80 (0.49 to 1.28)	1	0.71 (0.52 to 0.98)	0.71 (0.49 to 1.03)	0.90 (0.62 to 1.29)	0.99 (0.94 to 1.04)	p=0.68
Respiratory disease
No of deaths	9	52	47	38	35
Relative rate	0.76 (0.37 to 1.54)	1	1.06 (0.71 to 1.58)	1.36 (0.89 to 2.07)	1.51 (0.98 to 2.33)	1.06 (1.00 to 1.11)	p=0.043
Accidents/violence
No of deaths	3	19	24	10	8
Relative rate	0.66 (0.20 to 2.24)	1	1.67 (0.91 to 3.06)	1.16 (0.53 to 2.50)	1.11 (0.48 to 2.54)	1.02 (0.93 to 1.12)	p=0.67