HDL cholesterol and risk of stroke in quartiles of the distribution
| First quartile | Second quartile | Third quartile | Fourth quartile | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Stroke | Cases | Cases | Cases | Cases | Trend† | ||||
| Odds ratios with 95% CI relative to the first quartile of HDL cholesterol, adjusted for age, body mass index, systolic blood pressure, curent smoking and diabetes mellitus. The number of controls among men in the respective quartiles were 162, 103, 154, 91. The number of controls among women in the respective quartiles were 46, 33, 115, 121. *Cut off points were 0.95, 1.16 and 1.37 mmol/l for men and; 1.12, 1.35 and 1.60 mmol/l for women; †trends: odds ratio per 1 mmol/l increase in HDL cholesterol; ‡ischaemic stroke including unspecified stroke events. | |||||||||
| Men* | |||||||||
| All | 77 | 1.0 | 47 | 0.79 (0.51 to 1.26) | 63 | 0.98 (0.61 to 1.57) | 28 | 0.71 (0.44 to 1.14) | 0.71 (0.42 to 1.20) |
| Fatal | 17 | 1.0 | 10 | 0.65 (0.27 to 1.54) | 10 | 0.57 (0.21 to 1.51) | 9 | 0.86 (0.37 to 1.95) | 0.90 (0.33 to 2.41) |
| Non-fatal | 10 | 1.0 | 37 | 0.82 (0.50 to 1.34) | 53 | 1.10 (0.67 to 1.82) | 19 | 0.65 (0.38 to 1.11) | 0.66 (0.37 to 1.19) |
| Haemorrhagic | 8 | 1.0 | 8 | 0.85 (0.29 to 2.47) | 6 | 0.67 (0.19 to 2.37) | 8 | 1.35 (0.51 to 3.57) | 1.20 (0.40 to 3.63) |
| Ischaemic | 56 | 1.0 | 34 | 0.79 (0.47 to 1.32) | 50 | 1.16 (0.70 to 1.92) | 16 | 0.56 (0.32 to 0.98) | 0.65 (0.35 to 1.19) |
| Ischaemic‡ | 69 | 1.0 | 39 | 0.77 (0.48 to 1.24) | 57 | 1.01 (0.62 to 1.64) | 20 | 0.60 (0.36 to 1.00) | 0.62 (0.35 to 1.12) |
| Women* | |||||||||
| All | 17 | 1.0 | 13 | 0.62 (0.29 to 1.33) | 26 | 1.15 (0.54 to 2.43) | 49 | 1.27 (0.65 to 2.47) | 1.93 (1.00 to 3.70) |
| Fatal | 5 | 1.0 | 7 | 0.74 (0.18 to 2.96) | 8 | 1.83 (0.53 to 6.33) | 12 | 0.73 (0.21 to 2.59) | 0.87 (0.22 to 3.27) |
| Non-fatal | 12 | 1.0 | 6 | 0.62 (0.26 to 1.44) | 18 | 0.99 (0.42 to 2.35) | 37 | 1.49 (0.72 to 3.09) | 2.46 (1.20 to 5.04) |
| Haemorrhagic | 1 | 1.0 | 2 | No cases | 2 | 1.97 (0.38 to 10.1) | 6 | 1.18 (0.24 to 5.85) | 1.49 (0.26 to 8.67) |
| Ischaemic | 9 | 1.0 | 6 | 0.74 (0.30 to 1.85) | 18 | 1.21 (0.48 to 3.07) | 29 | 1.63 (0.73 to 3.64) | 2.52 ( 1.15 to 5.50) |
| Ischaemic‡ | 16 | 1.0 | 11 | 0.68 (0.31 to 1.50) | 23 | 1.06 (0.47 to 2.37) | 43 | 1.32 (0.66 to 2.64) | 2.02 (1.02 to 4.01) |