Case-control studies on cancer and WBC-DNA adducts (P32-postlabelling or enzyme linked immunosorbent assay, ELISA) (from Vineis and Perera23)
| Authors and method | Type of cancer | OR (95% CI) |
|---|---|---|
| Adducts are expressed as RAL × 10−8; estimates adjusted for age, smoking, gender, ethnicity, and (Peluso) fruit and vegetable intake. OR, odds ratio; CI, confidence intervals. | ||
| Peluso et al, 2000 | bladder | 5.25 (2.2 to 12.4) |
| Quartiles of DNA adducts | ||
| <0.1 | 1.0 – | |
| 0.1–0.23 | 3.0 (1.45 to 6.1) | |
| 0.24–0.51 | 5.4 (2.5 to 11.7) | |
| >0.51 | 7.9 (3.4 to 18.4) | |
| Vulimiri et al, 2000 | lung | mean adducts (per 108 nucleotides): cases 6.03 (1.16 SE) controls 2.80 (0.36 SE) (c) |
| Hou et al, 1999 | lung | 4.1 × 10−8 in both cases and controls |
| Li et al, 1996 | lung | 6.4 (1.3 to 29.4) |
| Tang et al, 1995, ELISA | lung | 7.7 (1.7 to 34) |