Characteristics of responders compared with non-responders
| Responders (n=719) | Non-responders (n=345) | p Value | |||||
|---|---|---|---|---|---|---|---|
| *Family history refers to first degree relatives. †Creatinine kinase only measured in patients whose working diagnosis was AMI. The CK iso-enzyme CK-MB should be used, but it was only measured at follow up in 156 (21.7%) patients, so the CPK was used in the analysis instead. | |||||||
| Sociodemographic characteristics | |||||||
| Male | 382 | (53.1) | 179 | (51.9) | 0.70 | ||
| Mean age (y) | 62.2 | 61.8 | 0.44 | ||||
| White | 686 | (95.4) | 316 | (91.6) | 0.015 | ||
| Carstairs mean deprivation score | −0.18 | n=652 | 0.37 | n=318 | 0.003 | ||
| Regular smoker | 227 | (43.5) | n=522 | 124 | (51.2) | n=242 | 0.05 |
| Alcohol (ever) | 612 | (89.1) | n=686 | 265 | (87.2) | n=304 | 0.35 |
| Family history* | |||||||
| Hypertension | 221 | (32.7) | n=675 | 107 | (36.0) | n=297 | 0.45 |
| Coronary artery disease | 437 | (64.5) | n=677 | 184 | (60.5) | n=304 | 0.16 |
| Hypercholesterolaemia | 81 | (12.1) | n=670 | 32 | (10.8) | n=297 | 0.59 |
| Past medical history | |||||||
| Diabetes | 70 | (10.2) | n=684 | 43 | (13.9) | n=309 | 0.09 |
| Hypertension | 247 | (36.6) | n=674 | 123 | (40.9) | n=301 | 0.21 |
| Angina | 296 | (43.9) | n=674 | 155 | (51.0) | n=304 | 0.04 |
| Acute myocardial infarction | 232 | (34.6) | n=670 | 126 | (41.7) | n=302 | 0.03 |
| Hypercholesterolaemia | 187 | (28.6) | n=654 | 82 | (28.3) | n=290 | 0.92 |
| Previous CABG | 46 | (6.7) | n=683 | 28 | (9.1) | n=307 | 0.19 |
| Previous PTCA | 40 | (5.8) | n=684 | 22 | (7.1) | n=308 | 0.44 |
| Previous angiogram | 78 | (72.2) | n=108 | 38 | (66.7) | n=57 | 0.46 |
| Indicators of disease severity | |||||||
| Q wave infarction | 251 | (65.5) | n=383 | 115 | (74.2) | n=155 | 0.05 |
| Clinical / radiological evidence of heart failure during admission | 141 | (19.9) | n=708 | 88 | (26.4) | n=333 | 0.03 |
| Abnormal CK† | 326 | (55.0) | n=593 | 132 | (48.9) | n=270 | 0.10 |
| Recurrence of signs / symptoms of ischaemia | 277 | (39.2) | n=706 | 120 | (35.7) | n=336 | 0.27 |
| If recurrent ischaemia, mean number of times (median, interquartile range) | 6.40 | (2.0, 1.0–4.0) | n=272 | 3.62 | (2.0, 1.0–4.3) | n=114 | 0.61 |
| Mean duration of pre-discharge exercise test [mins] (median, interquartile range) | 7.41 | (7.1, 4.5–9.5) | n=80 | 6.48 | (6.4, 4.0–9.0) | n=31 | 0.28 |
| Discharge diagnosis | |||||||
| Acute myocardial infarction | 383 | (54.3) | n=705 | 155 | (46.7) | n=330 | 0.03 |
| Angina | 271 | (38.4) | n=705 | 133 | (40.8) | n=326 | 0.47 |
| Non-cardiac cause | 20 | (2.8) | n=705 | 15 | (4.5) | n=331 | 0.16 |
| Further investigation required | 28 | (4.0) | n=704 | 22 | (6.7) | n=326 | 0.05 |
| Diagnostic procedures and follow up plans | |||||||
| Echocardiogram | 103 | (14.3) | 34 | (9.9) | 0.04 | ||
| Radionucleotide ventriculography | 6 | (0.8) | 2 | (0.6) | 0.65 | ||
| Thallium scan | 1 | (0.1) | 1 | (0.3) | 0.60 | ||
| On site angiogram | 18 | (2.7) | n=677 | 16 | (4.9) | n=326 | 0.07 |
| Pre-discharge exercise test | 83 | (11.7) | n=710 | 31 | (9.3) | n=335 | 0.24 |
| Local outpatient appointment | 614 | (88.3) | n=695 | 260 | (84.1) | n=309 | 0.07 |
| Cardiac rehab. course | 274 | (41.9) | n=654 | 84 | (29.5) | n=285 | 0.0001 |
| Follow up plan for on site angiogram | 26 | (4.1) | n=632 | 16 | (5.6) | n=285 | 0.32 |
| Referral to regional centre | 119 | (18.3) | n=650 | 47 | (16.5) | n=284 | 0.52 |