Table 4

Association between lifetime economic distress and onset of perimenopause, stratified by smoking status and body mass index at baseline, among 603 women from the Harvard Study of Moods and Cycles, Boston, Massachusetts, 1996–2000

		All women
	Total (n=603)	Crude IR (cases/1000 woman years)	Crude IRR (95% CI)	Adjusted IRR* (95% CI)	Adjusted IRR† (95% CI)
*Model adjusted for age at baseline, age at menarche, parity, years of oral contraceptive use, family history of early menopause. †Model additionally adjusted for race/ethnicity, depression, and BMI (in smoking models) or smoking (in BMI models).
Never smokers (n=330)
Economic distress across lifecourse:
Never	233	139	1.00	1.00	1.00
As child but not adult	38	197	1.39 (0.78 to 2.47)	1.41 (0.79 to 2.54)	1.27 (0.69 to 2.32)
As adult but not child	35	95	0.69 (0.33 to 1.43)	0.60 (0.29 to 1.28)	0.51 (0.24 to 1.09)
As both child and adult	24	204	1.51 (0.80 to 2.86)	1.61 (0.84 to 3.11)	1.32 (0.66 to 2.66)
Ever smokers (n=273)
Economic distress across lifecourse:
Never	167	111	1.00	1.00	1.00
As child but not adult	35	103	0.93 (0.43 to 1.98)	0.73 (0.33 to 1.60)	0.71 (0.31 to 1.63)
As adult but not child	49	186	1.64 (0.95 to 2.87)	1.55 (0.87 to 2.78)	1.39 (0.76 to 2.54)
As both child and adult	22	238	2.12 (1.06 to 4.24)	2.01 (0.99 to 4.11)	1.86 (0.89 to 3.89)
BMI <25 (n=406)
Economic distress across lifecourse:
Never	289	113	1.00	1.00	1.00
As child but not adult	12	140	1.20 (0.65 to 2.22)	1.16 (0.62 to 2.16)	1.20 (0.64 to 2.25)
As adult but not child	16	142	1.23 (0.71 to 2.11)	1.25 (0.72 to 2.16)	1.15 (0.66 to 2.02)
As both child and adult	10	227	2.06 (1.06 to 3.99)	2.17 (1.10 to 4.29)	1.98 (0.99 to 3.97)
BMI 25+ (n=197)
Economic distress across lifecourse:
Never	111	165	1.00	1.00	1.00
As child but not adult	30	159	0.97 (0.48 to 1.95)	0.89 (0.43 to 1.84)	0.88 (0.41 to 1.86)
As adult but not child	32	147	0.90 (0.45 to 1.80)	0.91 (0.44 to 1.88)	0.78 (0.37 to 1.66)
As both child and adult	24	212	1.30 (0.66 to 2.54)	1.27 (0.63 to 2.57)	1.04 (0.50 to 2.15)