Haemorrhagic and ischaemic stroke rates by cholesterol in men and women aged 45–64 from the Renfrew/Paisley study in 20 years of follow up
| Cholesterol quintile (mmol/l) | ||||||||
|---|---|---|---|---|---|---|---|---|
| For men | ⩽5.08 | 5.09–5.59 | 5.60–6.09 | 6.10–6.68 | ⩾6.69 | Trend1-150 | Relative rate associated with 1 standard deviation increase in cholesterol | |
| For women | ⩽5.57 | 5.58–6.09 | 6.10–6.60 | 6.61–7.28 | ⩾7.29 | |||
| Number of participants | 3276 | 3070 | 3038 | 3116 | 2767 | |||
| All stroke | ||||||||
| Number of strokes | 199 | 216 | 195 | 209 | 200 | |||
| Age adjusted rate | 45.7 | 51.1 | 43.9 | 45.7 | 49.4 | |||
| Relative rate1-151 | 1 | 1.10 | 0.95 | 0.98 | 1.07 | 0.71 | 0.99 | |
| (95% CI) | (0.90, 1.33) | (0.78, 1.16) | (0.81, 1.19) | (0.88, 1.30) | (0.93, 1.05) | |||
| Relative rate1-152 | 1 | 1.05 | 0.93 | 0.96 | 1.01 | 0.84 | 0.99 | |
| (95% CI) | (0.86, 1.27) | (0.76, 1.13) | (0.79, 1.17) | (0.83, 1.23) | (0.93, 1.06) | |||
| Haemorrhagic | ||||||||
| Number of strokes | 23 | 22 | 17 | 23 | 5 | |||
| Age adjusted rate | 4.6 | 4.9 | 3.2 | 4.5 | 1.1 | |||
| Relative rate1-151 | 1 | 0.97 | 0.73 | 0.95 | 0.23 | 0.017 | 0.76 | |
| (95% CI) | (0.54, 1.74) | (0.39, 1.36) | (0.53, 1.69) | (0.09, 0.61) | (0.61, 0.95) | |||
| Relative rate1-152 | 1 | 0.92 | 0.71 | 0.92 | 0.22 | 0.011 | 0.74 | |
| (95% CI) | (0.51, 1.65) | (0.38, 1.34) | (0.52, 1.65) | (0.08, 0.57) | (0.59, 0.94) | |||
| Ischaemic | ||||||||
| Number of strokes | 50 | 41 | 35 | 50 | 60 | |||
| Age adjusted rate | 11.5 | 9.3 | 7.6 | 11.8 | 14.5 | |||
| Relative rate1-151 | 1 | 0.85 | 0.70 | 0.98 | 1.35 | 0.08 | 1.12 | |
| (95% CI) | (0.56, 1.28) | (0.46, 1.08) | (0.66, 1.45) | (0.93, 1.96) | (0.99, 1.28) | |||
| Relative rate1-152 | 1 | 0.82 | 0.70 | 0.97 | 1.30 | 0.12 | 1.11 | |
| (95% CI) | (0.54, 1.24) | (0.45, 1.07) | (0.66, 1.44) | (0.89, 1.89) | (0.97, 1.26) | |||
↵1-150 Using cholesterol as a continuous variable.
↵1-151 Adjusted for age and sex.
↵1-152 Adjusted for age, sex, diastolic blood pressure, height, smoking (cigarettes per day and a 0/1 term for ex-smokers) and pre-existing coronary heart disease (angina, severe chest pain lasting half an hour or more, or ischaemia on electrocardiogram).