RT Journal Article
SR Electronic
T1 Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake
JF Journal of Epidemiology and Community Health
JO J Epidemiol Community Health
FD BMJ Publishing Group Ltd
SP 861
OP 866
DO 10.1136/jech-2022-219074
VO 76
IS 10
A1 Collatuzzo, Giulia
A1 Alicandro, Gianfranco
A1 Bertuccio, Paola
A1 Pelucchi, Claudio
A1 Bonzi, Rossella
A1 Palli, Domenico
A1 Ferraroni, Monica
A1 Ye, Weimin
A1 Plymoth, Amelie
A1 Zaridze, David
A1 Maximovich, Dmitry
A1 Aragones, Nuria
A1 Castaño-Vinyals, Gemma
A1 Vioque, Jesus
A1 Garcia de la Hera, Manoli
A1 Zhang, Zuo-Feng
A1 Hu, Jinfu
A1 Lopez-Carrillo, Lizbeth
A1 López-Cervantes, Malaquías
A1 Dalmartello, Michela
A1 Mu, Lina
A1 Ward, Mary H
A1 Rabkin, Charles
A1 Yu, Guo-Pei
A1 Camargo, M Constanza
A1 Curado, Maria Paula
A1 Lunet, Nuno
A1 Negri, Eva
A1 La Vecchia, Carlo
A1 Boffetta, Paolo
YR 2022
UL http://jech.bmj.com/content/76/10/861.abstract
AB Background Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC.Methods We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC.Results PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC.Conclusions Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.Data are available upon reasonable request. The data that support the findings of this study are available from the corresponding author upon reasonable request and approval by members of StoP Project Consortium.