TY - JOUR T1 - Substitutions of physical activity, sedentary behaviour and sleep: associations with mental health in middle-aged and elderly persons JF - Journal of Epidemiology and Community Health JO - J Epidemiol Community Health SP - 175 LP - 181 DO - 10.1136/jech-2020-215883 VL - 76 IS - 2 AU - Amy Hofman AU - Trudy Voortman AU - M. Arfan Ikram AU - Annemarie I Luik Y1 - 2022/02/01 UR - http://jech.bmj.com/content/76/2/175.abstract N2 - Background Physical activity, sedentary behaviour and sleep are potential risk factors of mental health disorders, but previous studies have not considered the dependency between these activity domains. Therefore, we examined the associations of reallocations of time among older adults’ physical activity, sedentary behaviour and sleep with depressive and anxiety symptoms using compositional isotemporal substitution analyses.Methods We included 1943 participants (mean age 71 years, SD: 9; 52% women) from the population-based Rotterdam Study. Between 2011 and 2016, we collected accelerometer data (mean duration 5.8 days, SD: 0.4) on physical activity, sedentary behaviour and sleep and self-reported data on depressive symptoms and anxiety.Results A reallocation of 30 min more moderate-to-vigorous physical activity was associated with a −0.55 (95% CI −1.04 to −0.06) points lower depressive symptoms score when replacing sleep and a −0.59 (95% CI −1.06 to −0.12) points lower score when replacing sedentary behaviour, but not when replacing light physical activity (−0.70, 95% CI −1.63 to 0.24). No associations were found for anxiety.Conclusion Replacing sedentary behaviour or sleep with more moderate-to-vigorous physical activity was associated with less depressive symptoms, suggesting that mainly intensive types of physical activity are important for middle-aged and older adults in relation to depressive symptoms.Data are available on reasonable request. Requests should be directed towards the management team of the Rotterdam Study (secretariat.epi@erasmusmc.nl), which has a protocol for approving data requests. Because of restrictions based on privacy regulations and informed consent of the participants, data cannot be made freely available in a public repository. ER -