TY - JOUR T1 - Paternal smoking and spontaneous abortion: a population-based retrospective cohort study among non-smoking women aged 20–49 years in rural China JF - Journal of Epidemiology and Community Health JO - J Epidemiol Community Health SP - 783 LP - 789 DO - 10.1136/jech-2017-210311 VL - 72 IS - 9 AU - Long Wang AU - Ying Yang AU - Fangchao Liu AU - Aimin Yang AU - Qin Xu AU - Qiaomei Wang AU - Haiping Shen AU - Yiping Zhang AU - Donghai Yan AU - Zuoqi Peng AU - Yuan He AU - Yuanyuan Wang AU - Jihong Xu AU - Jun Zhao AU - Hongguang Zhang AU - Ya Zhang AU - Qiaoyun Dai AU - Xu Ma Y1 - 2018/09/01 UR - http://jech.bmj.com/content/72/9/783.abstract N2 - Background To comprehensively evaluate the association of paternal smoking and spontaneous abortion.Methods We conducted a population-based retrospective cohort study among 5 770 691 non-smoking rural Chinese women, along with their husbands, participating in the National Free Pre-Pregnancy Checkups Project, regarding outcome events that occurred in 2010–2016. The main outcome was spontaneous abortion (SA). Multivariable logistic regression was used to estimate OR and 95% CI, and restricted cubic spline was used to estimate the non-linear relationship.Results The multivariable-adjusted OR of exposure to paternal smoking for SA was 1.17 (95% CI 1.16 to 1.19), compared with women without exposure to paternal smoking; and corresponding OR of exposure to preconception paternal smoking for SA was 1.11 (95% CI 1.08 to 1.14), compared with women without exposure to preconception paternal smoking. The ORs of preconception paternal smoking also increased with increases in paternal smoking (pnonlinear<0.05, almost linearly shaped) and preconception paternal smoking (pnonlinear>0.05). In addition, periconception paternal smoking cessation was associated with an 18% (15%–22%) lower risk of SA.Conclusion Paternal smoking was associated with SA. The importance of tobacco control, specifically pertaining to paternal smoking, should be emphasised during preconception and pregnancy counselling. ER -