RT Journal Article SR Electronic T1 Maternal polycystic ovarian syndrome and offspring growth: the Upstate KIDS Study JF Journal of Epidemiology and Community Health JO J Epidemiol Community Health FD BMJ Publishing Group Ltd SP 852 OP 855 DO 10.1136/jech-2017-210004 VO 72 IS 9 A1 Bell, Griffith A A1 Sundaram, Rajeshwari A1 Mumford, Sunni L A1 Park, Hyojun A1 Broadney, Miranda A1 Mills, James L A1 Bell, Erin M A1 Yeung, Edwina H YR 2018 UL http://jech.bmj.com/content/72/9/852.abstract AB Background Polycystic ovarian syndrome (PCOS) is the most common cause of female infertility and is associated with higher levels of circulating androgens. Exposure to higher levels of androgens in utero may be a risk factor for obesity among children of women with PCOS.Methods We examined whether maternal PCOS was associated with differences in offspring growth and obesity in the Upstate KIDS study, a prospective cohort study of infants born in New York State (excluding New York City) oversampled for fertility treatments and multiple births. Measurements of offspring length/height and weight were recorded at doctor’s visits through 3 years of age. PCOS diagnosis was self-reported by mothers at baseline. We used linear mixed models with robust SEs to estimate differences in growth by maternal PCOS exposure. We used logistic regression to examine whether infants experienced rapid weight gain at 4, 9 and 12 months. Growth measures were reported by 4098 mothers for 4949 children (1745 twins). Of these, 435 mothers (10.6%) had a diagnosis of PCOS.Results Compared with children born to mothers without PCOS, children of mothers with PCOS did not have significant differences in weight (4.81 g, 95% CI −95.1 to 104.7), length/height (0.18 cm, 95% CI −0.16 to 0.52) and body mass index (−0.14 kg/m2, 95% CI −0.30 to 0.01) through 3 years of age. We also observed no association between maternal PCOS and offspring rapid weight gain.Conclusions Overall, we found little evidence to suggest that maternal PCOS influences early childhood growth in this large, prospective cohort study.