TY - JOUR T1 - Cross-sectional relationship between haemoglobin concentration and measures of physical and cognitive function in an older rural South African population JF - Journal of Epidemiology and Community Health JO - J Epidemiol Community Health SP - 796 LP - 802 DO - 10.1136/jech-2018-210449 VL - 72 IS - 9 AU - Collin F Payne AU - Justine I Davies AU - F Xavier Gomez-Olive AU - Katherine J Hands AU - Kathleen Kahn AU - Lindsay C Kobayashi AU - Brent Tipping AU - Stephen M Tollman AU - Alisha Wade AU - Miles D Witham Y1 - 2018/09/01 UR - http://jech.bmj.com/content/72/9/796.abstract N2 - Background Age cohort differences in haemoglobin concentrations and associations with physical and cognitive performance among populations of lower income and middle-income countries have not previously been described. We examined the association between these factors among older men and women in rural South Africa.Methods We analysed cross-sectional data from a population-based study of rural South African men and women aged 40 and over (n=4499), with data drawn from questionnaire responses, a cognitive battery, objective physical function tests and blood tests. Anaemia was defined as a haemoglobin concentration <12 g/dL for women and <13 g/dL for men. We related haemoglobin concentrations to each of age, grip strength, walk speed and a latent cognitive function z-score for men and women separately. We used unadjusted correlations and linear models to adjust for comorbidities and inflammation.Results In total, 1042 (43.0%) women and 833 (40.1%) men were anaemic. Haemoglobin concentrations were inversely correlated with age for men but not for women; in adjusted analyses, haemoglobin was 0.3 g/dL lower per decade older for men (95% CI 0.2 to 0.4 g/dL). In adjusted analyses, haemoglobin concentration was independently associated with grip strength in women (B=0.391, 95% CI 0.177 to 0.605), but this did not reach significance in men (B=0.266, 95% CI −0.019 to 0.552); no associations were observed between haemoglobin levels and walk speed or cognitive score.Conclusions Anaemia was prevalent in this study population of middle-aged and older, rural South African adults, but in contrast to high-income countries, it was not associated with poor physical or cognitive function. Our findings need to be replicated in other populations. ER -