PT  - JOURNAL ARTICLE
AU  - Henriksson, Malin
AU  - Nyberg, Jenny
AU  - Schiöler, Linus
AU  - Hensing, Gunnel
AU  - Kuhn, Georg H
AU  - Söderberg, Mia
AU  - Torén, Kjell
AU  - Löve, Jesper
AU  - Waern, Margda
AU  - Åberg, Maria
TI  - Cause-specific mortality in Swedish males diagnosed with non-psychotic mental disorders in late adolescence: a prospective population-based study
AID  - 10.1136/jech-2018-210461
DP  - 2018 Jul 01
TA  - Journal of Epidemiology and Community Health
PG  - 582--588
VI  - 72
IP  - 7
4099  - http://jech.bmj.com/content/72/7/582.short
4100  - http://jech.bmj.com/content/72/7/582.full
SO  - J Epidemiol Community Health2018 Jul 01; 72
AB  - Background While risk of premature death is most pronounced among persons with severe mental illness, also milder conditions are associated with increased all-cause mortality. We examined non-psychotic mental (NPM) disorders and specific causes of natural death in a cohort of late adolescent men followed for up to 46 years.Methods Prospective cohort study of Swedish males (n=1 784 626) who took part in structured conscription interviews 1968–2005. 74 525 men were diagnosed with NPM disorders at or prior to conscription. Median follow-up time was 26 years. HRs for cause-specific mortality were calculated using Cox proportional hazards models.Results Risks in fully adjusted models were particularly elevated for death by infectious diseases (depressive and neurotic/adjustment disorders (HR 2.07; 95% CI 1.60 to 2.67), personality disorders (HR 2.90; 95% CI 1.96 to 4.28) and alcohol-related and other substance use disorders (HR 9.02; 95% CI 6.63 to 12.27)) as well as by gastrointestinal causes (depressive and neurotic/adjustment disorders (HR 1.64; 95% CI 1.42 to 1.89), personality disorders (HR 2.77; 95% CI 2.27 to 3.38) and alcohol-related/substance use disorders (HR 4.41; 95% CI 3.59 to 5.42)).Conclusion Young men diagnosed with NPM disorders had a long-term increased mortality risk, in particular due to infectious and gastrointestinal conditions. These findings highlight the importance of early preventive actions for adolescents with mental illness.