PT  - JOURNAL ARTICLE
AU  - A Boillot
AU  - H Range
AU  - N Danchin
AU  - S Kotti
AU  - G Cosler
AU  - S Czernichow
AU  - O Meilhac
AU  - E Puymirat
AU  - M Zeller
AU  - D Tchetche
AU  - P Bouchard
AU  - T Simon
TI  - Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)
AID  - 10.1136/jech-2015-207043
DP  - 2016 Dec 01
TA  - Journal of Epidemiology and Community Health
PG  - 1236--1241
VI  - 70
IP  - 12
4099  - http://jech.bmj.com/content/70/12/1236.short
4100  - http://jech.bmj.com/content/70/12/1236.full
SO  - J Epidemiol Community Health2016 Dec 01; 70
AB  - Background Periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (AMI). The present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (MI) at 1 year in 975 patients admitted for acute ST segment or non-ST segment elevation MI in French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI), a nationwide French survey.Methods Multiserotype ELISAs were performed to assess levels of IgG and IgA against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Tannerella forsythia.Results Adjusted HRs indicate the lack of association between IgG-anti-Po. gingivalis levels (0.96 (0.78 to 1.18)), IgA-anti-Po. gingivalis levels (1.13 (0.90 to 1.42)) and the risk of all-cause death or non-fatal MI at 1 year. Additionally, no significant association was found between the occurence of an event at 1 year and immunoglobulins levels against the others periodontopathogens.Conclusions The present data indicate that circulating levels of periodontopathogens antibodies are not associated with an increased risk of major adverse events in patients with a prior AMI. Studies dealing with bacterial and clinical data are needed to assess the role of oral health in comprehensive cardiac rehabilitation programmes.