PT - JOURNAL ARTICLE AU - Jochen Klenk AU - Michael Denkinger AU - Thorsten Nikolaus AU - Richard Peter AU - Dietrich Rothenbacher AU - Wolfgang Koenig AU - the ActiFE Study Group TI - Association of objectively measured physical activity with established and novel cardiovascular biomarkers in elderly subjects: every step counts AID - 10.1136/jech-2012-201312 DP - 2013 Feb 01 TA - Journal of Epidemiology and Community Health PG - 194--197 VI - 67 IP - 2 4099 - http://jech.bmj.com/content/67/2/194.short 4100 - http://jech.bmj.com/content/67/2/194.full SO - J Epidemiol Community Health2013 Feb 01; 67 AB - Objective To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment. Methods Between March 2009 and April 2010, physical activity was assessed in 1253 community-dwelling individuals living in Germany aged ≥65 years (57% men) over 1 week using a thigh-worn accelerometer. C reactive protein (CRP), white blood cells (WBC), N-terminal pro-brain natriuretic peptide, high-sensitive troponin T (hsTnT), creatinine (Cr) and cystatin C (CysC) were also measured. Least-square means of daily walking duration were calculated for quartiles of each biomarker adjusted for sex, age, pre-existing cardiovascular disease and smoking status. Results After adjustment for covariates, statistically significant linear associations with walking duration were observed for WBC, hsTnT, Cr and CysC. CRP quartiles 1 and 2 showed no significant difference followed by a significant inverse dose–response relationship. A similar pattern, but less pronounced, was seen for N-terminal pro-brain natriuretic peptide. Mean differences between the first two quartiles of CRP and its fourth quartile were 17 min. Between categories 1 (more beneficial) and 4 of WBC, hsTnT, Cr and CysC the differences were 15, 12, 23 and 20 min, respectively. Conclusion Increased walking duration is associated with a more favourable profile of cardiovascular biomarkers in elderly subjects.