RT Journal Article
SR Electronic
T1 Air pollution and asthma control in the Epidemiological study on the Genetics and Environment of Asthma
JF Journal of Epidemiology and Community Health
JO J Epidemiol Community Health
FD BMJ Publishing Group Ltd
SP 796
OP 802
DO 10.1136/jech.2010.130229
VO 66
IS 9
A1 Bénédicte Jacquemin
A1 Francine Kauffmann
A1 Isabelle Pin
A1 Nicole Le Moual
A1 Jean Bousquet
A1 Frédéric Gormand
A1 Jocelyne Just
A1 Rachel Nadif
A1 Christophe Pison
A1 Daniel Vervloet
A1 Nino Künzli
A1 Valérie Siroux
A1 on behalf of the Epidemiological study on the Genetics and Environment of Asthma (EGEA)
YR 2012
UL http://jech.bmj.com/content/66/9/796.abstract
AB Background The associations between exposure to air pollution and asthma control are not well known. The objective of this study was to assess the association between long-term exposure to NO2, O3 and PM10 and asthma control in the follow-up of the Epidemiological study on the Genetics and Environment of Asthma (EGEA2) (2003–2007).Methods Modelled outdoor NO2, O3 and PM10 estimates were linked to each residential address using the 4 km grid air pollutant surface developed by the French Institute of Environment in 2004. Asthma control was assessed in 481 subjects with current asthma using a multidimensional approach following the 2006–2009 Global Initiative for Asthma guidelines. Multinomial and ordinal logistic regressions were conducted adjusted for sex, age, body mass index, education, smoking and use of inhaled corticosteroids. The association between air pollution and the three domains of asthma control (symptoms, exacerbations and lung function) was assessed. ORs are reported per IQR.Results Median concentrations (in micrograms per cubic metre) were 32 (IQR 25–38) for NO2 (n=465), 46 (41–52) for O3 and 21 (18–21) for PM10 (n=481). In total, 44%, 29% and 27% had controlled, partly controlled and uncontrolled asthma, respectively. The ordinal ORs for O3 and PM10 with asthma control were 1.69 (95% CI 1.22 to 2.34) and 1.35 (95% CI 1.13 to 1.64), respectively. When including both pollutants in the same model, both associations persisted. Associations were not modified by sex, smoking status, use of inhaled corticosteroids, atopy, season of examination or body mass index. Both pollutants were associated with each of the three main domains of control.Conclusions The results suggest that long-term exposure to PM10 and O3 is associated with uncontrolled asthma in adults, defined by symptoms, exacerbations and lung function.